a tool for identifying drug-targetable redox-active disulphides

Myomesin-1

Intramolecular

Cysteine 1360 and cysteine 1393

A redox-regulated disulphide may form within Myomesin-1 between cysteines 1360 and 1393 (157 and 190 respectively in this structure).

Details

Redox score ?

78

PDB code

Structure name

skelemin association with alpha2b,beta3 integrin: a structural model

Structure deposition date

2014-09-19

Thiol separation (Å)

4

Half-sphere exposure sum ?

63

Minimum pK_a ?

8

% buried

58

Peptide accession

Residue number A

1360

Residue number B

1393

Peptide name

Myomesin-1

Ligandability

Cysteine 1360 of Myomesin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1393 of Myomesin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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