a tool for identifying drug-targetable redox-active disulphides

Rap1 GTPase-GDP dissociation stimulator 1

Intermolecular

Cysteine 117 and cysteine 190 of Transforming protein RhoA L

A redox-regulated disulphide may form between cysteine 117 of Rap1 GTPase-GDP dissociation stimulator 1 and cysteine 190 of Transforming protein RhoA. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

50

PDB code

Structure name

crystal structure of smggds-558 and farnesylated rhoa complex

Structure deposition date

2018-03-13

Thiol separation (Å)

7

Half-sphere exposure sum ?

64

Minimum pK_a ?

11

% buried

81

Peptide A name

Rap1 GTPase-GDP dissociation stimulator 1

Peptide B name

Transforming protein RhoA

Peptide A accession

Peptide B accession

Peptide A residue number

117

Peptide B residue number

190

Ligandability

Cysteine 117 of Rap1 GTPase-GDP dissociation stimulator 1

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 190 of Transforming protein RhoA

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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