ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcription initiation factor IIA subunit 1

Intermolecular
Cysteine 337 and cysteine 98 of Transcription initiation factor IIA subunit 2
Intramolecular
Cysteine 98 and cysteine 337
A redox-regulated disulphide may form between cysteine 337 of Transcription initiation factor IIA subunit 1 and cysteine 98 of Transcription initiation factor IIA subunit 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
1nvp
Structure name
human tfiia/tbp/dna complex
Structure deposition date
2003-02-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
69
Peptide A name
Transcription initiation factor IIA subunit 1
Peptide B name
Transcription initiation factor IIA subunit 2
Peptide A accession
P52655
Peptide B accession
P52657
Peptide A residue number
337
Peptide B residue number
98

Ligandability

Cysteine 337 of Transcription initiation factor IIA subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Transcription initiation factor IIA subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transcription initiation factor IIA subunit 1 between cysteines 98 and 337 (98 and 171 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
5m4s
Structure name
transcription factor tfiia as a single chain protein
Structure deposition date
2016-10-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
75
Peptide accession
P52655
Residue number A
98
Residue number B
337
Peptide name
Transcription initiation factor IIA subunit 1

Ligandability

Cysteine 98 of Transcription initiation factor IIA subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 337 of Transcription initiation factor IIA subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 in protein A could not be asigned to a Uniprot residue.
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