a tool for identifying drug-targetable redox-active disulphides

Transcription initiation factor IIA subunit 2

Intermolecular

Cysteine 337 of Transcription initiation factor IIA subunit 1 and cysteine 98

A redox-regulated disulphide may form between cysteine 337 of Transcription initiation factor IIA subunit 1 and cysteine 98 of Transcription initiation factor IIA subunit 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

38

PDB code

Structure name

human tfiia/tbp/dna complex

Structure deposition date

2003-02-04

Thiol separation (Å)

9

Half-sphere exposure sum ?

72

Minimum pK_a ?

10

% buried

69

Peptide A name

Transcription initiation factor IIA subunit 1

Peptide B name

Transcription initiation factor IIA subunit 2

Peptide A accession

Peptide B accession

Peptide A residue number

337

Peptide B residue number

98

Ligandability

Cysteine 337 of Transcription initiation factor IIA subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Transcription initiation factor IIA subunit 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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