Guanine nucleotide exchange factor VAV2

Intermolecular

Cysteine 749 and cysteine 333 of Thioredoxin-interacting protein

A redox-regulated disulphide may form between cysteine 749 of Guanine nucleotide exchange factor VAV2 and cysteine 333 of Thioredoxin-interacting protein.

Details

Redox score ?

PDB code

4roj

Structure name

crystal structure of the vav2 sh2 domain in complex with txnip phosphorylated peptide

Structure deposition date

2014-10-28

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Guanine nucleotide exchange factor VAV2

Peptide B name

Thioredoxin-interacting protein

Peptide A accession

P52735

Peptide B accession

Q9H3M7

Peptide A residue number

749

Peptide B residue number

333

Ligandability

Cysteine 749 of Guanine nucleotide exchange factor VAV2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.