ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ephrin-B2

Intramolecular
Cysteine 89 and cysteine 153
Cysteine 62 and cysteine 101
A redox-regulated disulphide may form within Ephrin-B2 between cysteines 89 and 153.

Details

Redox score ?
83
PDB code
6p7y
Structure name
crystal structure of the cedar henipavirus attachment g glycoprotein globular domain in complex with the receptor ephrin-b2
Structure deposition date
2019-06-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
P52799
Residue number A
89
Residue number B
153
Peptide name
Ephrin-B2

Ligandability

Cysteine 89 of Ephrin-B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Ephrin-B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ephrin-B2 between cysteines 62 and 101.

Details

Redox score ?
83
PDB code
6pdl
Structure name
crystal structure of hendra virus attachment g glycoprotein in complex with receptor ephrin-b2
Structure deposition date
2019-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P52799
Residue number A
62
Residue number B
101
Peptide name
Ephrin-B2

Ligandability

Cysteine 62 of Ephrin-B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Ephrin-B2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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