ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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F-actin-capping protein subunit alpha-1

Intramolecular
Cysteine 141 and cysteine 157
Cysteine 124 and cysteine 141 L
A redox-regulated disulphide may form within F-actin-capping protein subunit alpha-1 between cysteines 141 and 157. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
5afu
Structure name
cryo-em structure of dynein tail-dynactin-bicd2n complex
Structure deposition date
2015-01-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
A0PFK5
Residue number A
141
Residue number B
157
Peptide name
F-actin-capping protein subunit alpha-1

Ligandability

Cysteine 141 of F-actin-capping protein subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of F-actin-capping protein subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within F-actin-capping protein subunit alpha-1 between cysteines 124 and 141. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
6f1t
Structure name
cryo-em structure of two dynein tail domains bound to dynactin and bicdr1
Structure deposition date
2017-11-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
93
Peptide accession
A0PFK5
Residue number A
124
Residue number B
141
Peptide name
F-actin-capping protein subunit alpha-1

Ligandability

Cysteine 124 of F-actin-capping protein subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 141 of F-actin-capping protein subunit alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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