ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein FosB

Intermolecular
Cysteine 172 and cysteine 172
Cysteine 172 and cysteine 285 of Transcription factor JunD
A redox-regulated disulphide may form between two units of Protein FosB at cysteines 172 and 172.

Details

Redox score ?
81
PDB code
6uci
Structure name
transcription factor deltafosb bzip domain self-assembly, oxidized form
Structure deposition date
2019-09-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Protein FosB
Peptide B name
Protein FosB
Peptide A accession
P53539
Peptide B accession
P53539
Peptide A residue number
172
Peptide B residue number
172

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 172 of Protein FosB and cysteine 285 of Transcription factor JunD.

Details

Redox score ?
73
PDB code
5vpa
Structure name
transcription factor fosb/jund bzip domain
Structure deposition date
2017-05-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
0
Peptide A name
Protein FosB
Peptide B name
Transcription factor JunD
Peptide A accession
P53539
Peptide B accession
P17535
Peptide A residue number
172
Peptide B residue number
285

Ligandability

Cysteine 172 of Protein FosB

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 285 of Transcription factor JunD

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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