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Methionine aminopeptidase 1

Intramolecular
Cysteine 9 and cysteine 14 L
Cysteine 14 and cysteine 36 L
Cysteine 9 and cysteine 40
Cysteine 14 and cysteine 40 L
Cysteine 9 and cysteine 36
Cysteine 36 and cysteine 40
Cysteine 22 and cysteine 25
Cysteine 174 and cysteine 179 L
Cysteine 194 and cysteine 202
Cysteine 193 and cysteine 194
More...
Cysteine 174 and cysteine 193
Cysteine 202 and cysteine 331
Cysteine 9 and cysteine 22
A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 9 and 14 (30 and 35 respectively in this structure).

Details

Redox score ?
86
PDB code
7sek
Structure name
solution structure of the zinc finger domain of murine metap1, complexed with zng n-terminal peptide
Structure deposition date
2021-09-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
10
Peptide accession
Q8BP48
Residue number A
9
Residue number B
14
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 9 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 14 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 14 and 36 (35 and 57 respectively in this structure).

Details

Redox score ?
83
PDB code
7sek
Structure name
solution structure of the zinc finger domain of murine metap1, complexed with zng n-terminal peptide
Structure deposition date
2021-09-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
7
% buried
2
Peptide accession
Q8BP48
Residue number A
14
Residue number B
36
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 14 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 9 and 40 (30 and 61 respectively in this structure).

Details

Redox score ?
81
PDB code
7sek
Structure name
solution structure of the zinc finger domain of murine metap1, complexed with zng n-terminal peptide
Structure deposition date
2021-09-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
7
% buried
14
Peptide accession
Q8BP48
Residue number A
9
Residue number B
40
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 9 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 40 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 14 and 40 (35 and 61 respectively in this structure).

Details

Redox score ?
81
PDB code
7sek
Structure name
solution structure of the zinc finger domain of murine metap1, complexed with zng n-terminal peptide
Structure deposition date
2021-09-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
4
Peptide accession
Q8BP48
Residue number A
14
Residue number B
40
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 14 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 40 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 9 and 36 (30 and 57 respectively in this structure).

Details

Redox score ?
80
PDB code
7sek
Structure name
solution structure of the zinc finger domain of murine metap1, complexed with zng n-terminal peptide
Structure deposition date
2021-09-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
12
Peptide accession
Q8BP48
Residue number A
9
Residue number B
36
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 9 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 36 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 36 and 40 (57 and 61 respectively in this structure).

Details

Redox score ?
79
PDB code
7sek
Structure name
solution structure of the zinc finger domain of murine metap1, complexed with zng n-terminal peptide
Structure deposition date
2021-09-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
5
Peptide accession
Q8BP48
Residue number A
36
Residue number B
40
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 36 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 40 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 22 and 25 (43 and 46 respectively in this structure).

Details

Redox score ?
76
PDB code
7sek
Structure name
solution structure of the zinc finger domain of murine metap1, complexed with zng n-terminal peptide
Structure deposition date
2021-09-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
40
Peptide accession
Q8BP48
Residue number A
22
Residue number B
25
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 22 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 25 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 174 and 179 (183 and 188 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
4u75
Structure name
hsmetap (f309m) in complex with methionine
Structure deposition date
2014-07-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
88
Peptide accession
P53582
Residue number A
174
Residue number B
179
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 174 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 179 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 194 and 202 (203 and 211 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2nq7
Structure name
crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-dimethylpropionylamino)pyridine-2-carboxylic acid thiazole-2-ylamide
Structure deposition date
2006-10-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
100
Peptide accession
P53582
Residue number A
194
Residue number B
202
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 194 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 193 and 194 (202 and 203 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4u69
Structure name
hsmetap complex with (1-amino-2-methylpentyl)phosphonic acid
Structure deposition date
2014-07-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
91
Minimum pKa ?
13
% buried
100
Peptide accession
P53582
Residue number A
193
Residue number B
194
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 193 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 174 and 193 (183 and 202 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4u70
Structure name
hsmetap (f309m) in complex with (1-amino-2-cyclohexylethyl)phosphonic acid
Structure deposition date
2014-07-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
88
Minimum pKa ?
14
% buried
100
Peptide accession
P53582
Residue number A
174
Residue number B
193
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 174 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 202 and 331 (211 and 340 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
4iku
Structure name
crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with 2-((5-chloro-6-methyl-2- (pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide
Structure deposition date
2012-12-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
98
Peptide accession
P53582
Residue number A
202
Residue number B
331
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 202 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 331 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methionine aminopeptidase 1 between cysteines 9 and 22 (9 and 43 respectively in this structure).

Details

Redox score ?
nan
PDB code
7sek
Structure name
solution structure of the zinc finger domain of murine metap1, complexed with zng n-terminal peptide
Structure deposition date
2021-09-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
21
Peptide accession
Q8BP48
Residue number A
9
Residue number B
22
Peptide name
Methionine aminopeptidase 1

Ligandability

Cysteine 9 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 22 of Methionine aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 9 in protein A could not be asigned to a Uniprot residue.
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