ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Isoform I of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Intramolecular
Cysteine 142 and cysteine 172 L
Cysteine 223 and cysteine 239
Cysteine 172 and cysteine 239 L
A redox-regulated disulphide may form within Isoform I of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial between cysteines 142 and 172 (102 and 132 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2fpp
Structure name
crystal structure of pig gtp-specific succinyl-coa synthetase from polyethylene glycol with chloride ions
Structure deposition date
2006-01-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
99
Minimum pKa ?
13
% buried
100
Peptide accession
O19069-2
Residue number A
142
Residue number B
172
Peptide name
Isoform I of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Ligandability

Cysteine 142 of Isoform I of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 172 of Isoform I of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial between cysteines 223 and 239 (183 and 199 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
7msr
Structure name
human e105qa gtp-specific succinyl-coa synthetase complexed with succinyl-phosphate, magnesium ion and desulfo-coenzyme a
Structure deposition date
2021-05-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
13
% buried
100
Peptide accession
P53597
Residue number A
223
Residue number B
239
Peptide name
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Ligandability

Cysteine 223 of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial between cysteines 172 and 239 (132 and 199 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
7jj0
Structure name
gtp-specific succinyl-coa synthetase complexed with mg-gmppcp
Structure deposition date
2020-07-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
O19069
Residue number A
172
Residue number B
239
Peptide name
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Ligandability

Cysteine 172 of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 239 of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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