a tool for identifying drug-targetable redox-active disulphides

Diphosphomevalonate decarboxylase

Intramolecular

Cysteine 13 and cysteine 134

A redox-regulated disulphide may form within Diphosphomevalonate decarboxylase between cysteines 13 and 134 (12 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

50

PDB code

Structure name

mus musculus mevalonate pyrophosphate decarboxylase

Structure deposition date

2008-10-25

Thiol separation (Å)

6

Half-sphere exposure sum ?

93

Minimum pK_a ?

11

% buried

84

Peptide accession

Residue number A

13

Residue number B

134

Peptide name

Diphosphomevalonate decarboxylase

Ligandability

Cysteine 13 of Diphosphomevalonate decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Diphosphomevalonate decarboxylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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