ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Geranylgeranyl transferase type-1 subunit beta

Intramolecular
Cysteine 93 and cysteine 147
Cysteine 177 and cysteine 180
Cysteine 177 and cysteine 225
Cysteine 180 and cysteine 225
Cysteine 180 and cysteine 182
A redox-regulated disulphide may form within Geranylgeranyl transferase type-1 subunit beta between cysteines 93 and 147. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
1n4s
Structure name
protein geranylgeranyltransferase type-i complexed with ggpp and a geranylgeranylated kkksktkcvil peptide product
Structure deposition date
2002-11-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
81
Peptide accession
P53610
Residue number A
93
Residue number B
147
Peptide name
Geranylgeranyl transferase type-1 subunit beta

Ligandability

Cysteine 93 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 147 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-1 subunit beta between cysteines 177 and 180. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1tnb
Structure name
rat protein geranylgeranyltransferase type-i complexed with a ggpp analog and a substrate kksktkcvif peptide derived from tc21
Structure deposition date
2004-06-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
100
Peptide accession
P53610
Residue number A
177
Residue number B
180
Peptide name
Geranylgeranyl transferase type-1 subunit beta

Ligandability

Cysteine 177 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-1 subunit beta between cysteines 177 and 225. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
1tnb
Structure name
rat protein geranylgeranyltransferase type-i complexed with a ggpp analog and a substrate kksktkcvif peptide derived from tc21
Structure deposition date
2004-06-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
14
% buried
100
Peptide accession
P53610
Residue number A
177
Residue number B
225
Peptide name
Geranylgeranyl transferase type-1 subunit beta

Ligandability

Cysteine 177 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 225 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-1 subunit beta between cysteines 180 and 225. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
1n4p
Structure name
protein geranylgeranyltransferase type-i complexed with geranylgeranyl diphosphate
Structure deposition date
2002-11-01
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
100
Peptide accession
P53610
Residue number A
180
Residue number B
225
Peptide name
Geranylgeranyl transferase type-1 subunit beta

Ligandability

Cysteine 180 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 225 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-1 subunit beta between cysteines 180 and 182. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
1n4r
Structure name
protein geranylgeranyltransferase type-i complexed with a geranylgeranylated kkksktkcvil peptide product
Structure deposition date
2002-11-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
92
Peptide accession
P53610
Residue number A
180
Residue number B
182
Peptide name
Geranylgeranyl transferase type-1 subunit beta

Ligandability

Cysteine 180 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 182 of Geranylgeranyl transferase type-1 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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