ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Geranylgeranyl transferase type-2 subunit beta

Intermolecular
Cysteine 240 and cysteine 194 of Synaptobrevin homolog YKT6
Intramolecular
Cysteine 174 and cysteine 197
Cysteine 148 and cysteine 196
Cysteine 196 and cysteine 197
Cysteine 174 and cysteine 183
Cysteine 183 and cysteine 196
Cysteine 183 and cysteine 197
Cysteine 240 and cysteine 270
A redox-regulated disulphide may form between cysteine 240 of Geranylgeranyl transferase type-2 subunit beta and cysteine 194 of Synaptobrevin homolog YKT6.

Details

Redox score ?
72
PDB code
6j7f
Structure name
complex of ggtaseiii, farnesyl-ykt6 (c-terminal methylated), and ggpp
Structure deposition date
2019-01-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
100
Peptide A name
Geranylgeranyl transferase type-2 subunit beta
Peptide B name
Synaptobrevin homolog YKT6
Peptide A accession
P53611
Peptide B accession
O15498
Peptide A residue number
240
Peptide B residue number
194

Ligandability

Cysteine 240 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of Synaptobrevin homolog YKT6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit beta between cysteines 174 and 197. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6j74
Structure name
complex of ggtaseiii and full-length ykt6
Structure deposition date
2019-01-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
95
Peptide accession
P53611
Residue number A
174
Residue number B
197
Peptide name
Geranylgeranyl transferase type-2 subunit beta

Ligandability

Cysteine 174 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit beta between cysteines 148 and 196. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
6o60
Structure name
crystal structure of ggtase3-fbxl2-skp1 complex
Structure deposition date
2019-03-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
P53611
Residue number A
148
Residue number B
196
Peptide name
Geranylgeranyl transferase type-2 subunit beta

Ligandability

Cysteine 148 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit beta between cysteines 196 and 197. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6j7f
Structure name
complex of ggtaseiii, farnesyl-ykt6 (c-terminal methylated), and ggpp
Structure deposition date
2019-01-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
94
Minimum pKa ?
14
% buried
100
Peptide accession
P53611
Residue number A
196
Residue number B
197
Peptide name
Geranylgeranyl transferase type-2 subunit beta

Ligandability

Cysteine 196 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit beta between cysteines 174 and 183. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
1ltx
Structure name
structure of rab escort protein-1 in complex with rab geranylgeranyl transferase and isoprenoid
Structure deposition date
2002-05-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
96
Peptide accession
Q08603
Residue number A
174
Residue number B
183
Peptide name
Geranylgeranyl transferase type-2 subunit beta

Ligandability

Cysteine 174 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit beta between cysteines 183 and 196. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
3pz1
Structure name
crystal structure of rabggtase(delta lrr; delta ig) in complex with bms3
Structure deposition date
2010-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide accession
Q08603
Residue number A
183
Residue number B
196
Peptide name
Geranylgeranyl transferase type-2 subunit beta

Ligandability

Cysteine 183 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit beta between cysteines 183 and 197. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
4ehm
Structure name
rabggtase in complex with covalently bound psoromic acid
Structure deposition date
2012-04-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
14
% buried
100
Peptide accession
Q08603
Residue number A
183
Residue number B
197
Peptide name
Geranylgeranyl transferase type-2 subunit beta

Ligandability

Cysteine 183 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Geranylgeranyl transferase type-2 subunit beta between cysteines 240 and 270. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
3pz2
Structure name
crystal structure of rabggtase(delta lrr; delta ig) in complex with bms3 and lipid substrate ggpp
Structure deposition date
2010-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
100
Peptide accession
Q08603
Residue number A
240
Residue number B
270
Peptide name
Geranylgeranyl transferase type-2 subunit beta

Ligandability

Cysteine 240 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 270 of Geranylgeranyl transferase type-2 subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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