Coatomer subunit alpha
Intermolecular
Cysteine 34 of Coatomer subunit epsilon and cysteine 975
Intramolecular
Cysteine 1185 and cysteine 1201 L
Cysteine 127 and cysteine 129
Cysteine 1013 and cysteine 1057
Cysteine 140 and cysteine 254 L
Cysteine 1169 and cysteine 1191 L
Cysteine 1185 and cysteine 1191 L
Cysteine 1191 and cysteine 1201 L
3mkr A 34 B 975
A redox-regulated disulphide may form between cysteine 34 of Coatomer subunit epsilon and cysteine 975 of Coatomer subunit alpha. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
3mkr
Structure name
crystal structure of yeast alpha/epsilon-cop subcomplex of the copi vesicular coat
Structure deposition date
2010-04-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
88
Peptide A name
Coatomer subunit epsilon
Peptide B name
Coatomer subunit alpha
Peptide A accession
Q28104
Peptide B accession
Q27954
Peptide A residue number
34
Peptide B residue number
975
Ligandability
Cysteine 34 of Coatomer subunit epsilon
Cysteine 975 of Coatomer subunit alpha
6tzt D 1185 D 1201
A redox-regulated disulphide may form within Coatomer subunit alpha between cysteines 1185 and 1201.
Details
Redox score ?
81
PDB code
6tzt
Structure name
crystal structure of human alpha/epsilon-cop of the copi vesicular coat bound to alpha-cop stm2
Structure deposition date
2019-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
5
% buried
94
Peptide accession
P53621
Residue number A
1185
Residue number B
1201
Peptide name
Coatomer subunit alpha
Ligandability
Cysteine 1185 of Coatomer subunit alpha
Cysteine 1201 of Coatomer subunit alpha
6pbg A 127 A 129
A redox-regulated disulphide may form within Coatomer subunit alpha between cysteines 127 and 129. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
6pbg
Structure name
crystal structure of wd-repeat domain of human coatomer subunit alpha (copa)
Structure deposition date
2019-06-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P53621
Residue number A
127
Residue number B
129
Peptide name
Coatomer subunit alpha
Ligandability
Cysteine 127 of Coatomer subunit alpha
Cysteine 129 of Coatomer subunit alpha
3mkr B 1013 B 1057
A redox-regulated disulphide may form within Coatomer subunit alpha between cysteines 1013 and 1057. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
3mkr
Structure name
crystal structure of yeast alpha/epsilon-cop subcomplex of the copi vesicular coat
Structure deposition date
2010-04-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
80
Peptide accession
Q27954
Residue number A
1013
Residue number B
1057
Peptide name
Coatomer subunit alpha
Ligandability
Cysteine 1013 of Coatomer subunit alpha
Cysteine 1057 of Coatomer subunit alpha
6pbg A 140 A 254
A redox-regulated disulphide may form within Coatomer subunit alpha between cysteines 140 and 254. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
6pbg
Structure name
crystal structure of wd-repeat domain of human coatomer subunit alpha (copa)
Structure deposition date
2019-06-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
99
Minimum pKa ?
nan
% buried
nan
Peptide accession
P53621
Residue number A
140
Residue number B
254
Peptide name
Coatomer subunit alpha
Ligandability
Cysteine 140 of Coatomer subunit alpha
Cysteine 254 of Coatomer subunit alpha
6u3v B 1169 B 1191
A redox-regulated disulphide may form within Coatomer subunit alpha between cysteines 1169 and 1191. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6u3v
Structure name
crystal structure of human alpha/epsilon-cop of the copi vesicular coat bound to alpha-cop stm1
Structure deposition date
2019-08-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
7
% buried
62
Peptide accession
P53621
Residue number A
1169
Residue number B
1191
Peptide name
Coatomer subunit alpha
Ligandability
Cysteine 1169 of Coatomer subunit alpha
Cysteine 1191 of Coatomer subunit alpha
3mkr B 1185 B 1191
A redox-regulated disulphide may form within Coatomer subunit alpha between cysteines 1185 and 1191. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
3mkr
Structure name
crystal structure of yeast alpha/epsilon-cop subcomplex of the copi vesicular coat
Structure deposition date
2010-04-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
6
% buried
80
Peptide accession
Q27954
Residue number A
1185
Residue number B
1191
Peptide name
Coatomer subunit alpha
Ligandability
Cysteine 1185 of Coatomer subunit alpha
Cysteine 1191 of Coatomer subunit alpha
6u3v D 1191 D 1201
A redox-regulated disulphide may form within Coatomer subunit alpha between cysteines 1191 and 1201. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
6u3v
Structure name
crystal structure of human alpha/epsilon-cop of the copi vesicular coat bound to alpha-cop stm1
Structure deposition date
2019-08-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
84
Peptide accession
P53621
Residue number A
1191
Residue number B
1201
Peptide name
Coatomer subunit alpha
Ligandability
Cysteine 1191 of Coatomer subunit alpha
Cysteine 1201 of Coatomer subunit alpha
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