ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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AP-2 complex subunit sigma

Intermolecular
Cysteine 193 of Protein Nef and cysteine 97
Intramolecular
Cysteine 68 and cysteine 70
A redox-regulated disulphide may form between cysteine 193 of Protein Nef and cysteine 97 of AP-2 complex subunit sigma.

Details

Redox score ?
81
PDB code
6owt
Structure name
structure of sivsmm nef and smm tetherin bound to the clathrin adaptor ap-2 complex
Structure deposition date
2019-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
Protein Nef
Peptide B name
AP-2 complex subunit sigma
Peptide A accession
Q4JGV0
Peptide B accession
P62744
Peptide A residue number
193
Peptide B residue number
97

Ligandability

Cysteine 193 of Protein Nef

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of AP-2 complex subunit sigma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within AP-2 complex subunit sigma between cysteines 68 and 70. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
2jkt
Structure name
ap2 clathrin adaptor core with cd4 dileucine peptide rm( phosphos)eikrllse q to e mutant
Structure deposition date
2008-08-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
P62743
Residue number A
68
Residue number B
70
Peptide name
AP-2 complex subunit sigma

Ligandability

Cysteine 68 of AP-2 complex subunit sigma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of AP-2 complex subunit sigma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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