RecQ-like DNA helicase BLM
Intermolecular
Cysteine 380 and cysteine 380
Intramolecular
Cysteine 1055 and cysteine 1063
Cysteine 1036 and cysteine 1055
Cysteine 1063 and cysteine 1066
Cysteine 1036 and cysteine 1063
Cysteine 895 and cysteine 901
Cysteine 1036 and cysteine 1066
Cysteine 1063 and cysteine 1067
Cysteine 1066 and cysteine 1067
Cysteine 895 and cysteine 944
More...Cysteine 901 and cysteine 944
Cysteine 1055 and cysteine 1067
Cysteine 1055 and cysteine 1066
Cysteine 878 and cysteine 895
Cysteine 940 and cysteine 944
Cysteine 1218 and cysteine 1226
Cysteine 685 and cysteine 698 L
Cysteine 1036 and cysteine 1067
Cysteine 878 and cysteine 944
5mk5 A 380 B 380
A redox-regulated disulphide may form between two units of RecQ-like DNA helicase BLM at cysteines 380 and 380.
Details
Redox score ?
66
PDB code
5mk5
Structure name
structures of dhbn domain of human blm helicase
Structure deposition date
2016-12-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
82
Peptide A name
RecQ-like DNA helicase BLM
Peptide B name
RecQ-like DNA helicase BLM
Peptide A accession
P54132
Peptide B accession
P54132
Peptide A residue number
380
Peptide B residue number
380
Ligandability
4o3m A 1055 A 1063
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1055 and 1063.
Details
Redox score ?
86
PDB code
4o3m
Structure name
ternary complex of bloom's syndrome helicase
Structure deposition date
2013-12-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
3
% buried
49
Peptide accession
P54132
Residue number A
1055
Residue number B
1063
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1055 of RecQ-like DNA helicase BLM
Cysteine 1063 of RecQ-like DNA helicase BLM
7aud F 1036 F 1055
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1036 and 1055.
Details
Redox score ?
85
PDB code
7aud
Structure name
structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Structure deposition date
2020-11-02
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
42
Peptide accession
P54132
Residue number A
1036
Residue number B
1055
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1036 of RecQ-like DNA helicase BLM
Cysteine 1055 of RecQ-like DNA helicase BLM
4cdg B 1063 B 1066
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1063 and 1066.
Details
Redox score ?
83
PDB code
4cdg
Structure name
crystal structure of the bloom's syndrome helicase blm in complex with nanobody
Structure deposition date
2013-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
5
% buried
60
Peptide accession
P54132
Residue number A
1063
Residue number B
1066
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1063 of RecQ-like DNA helicase BLM
Cysteine 1066 of RecQ-like DNA helicase BLM
4o3m A 1036 A 1063
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1036 and 1063.
Details
Redox score ?
82
PDB code
4o3m
Structure name
ternary complex of bloom's syndrome helicase
Structure deposition date
2013-12-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
3
% buried
52
Peptide accession
P54132
Residue number A
1036
Residue number B
1063
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1036 of RecQ-like DNA helicase BLM
Cysteine 1063 of RecQ-like DNA helicase BLM
7aud D 895 D 901
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 895 and 901.
Details
Redox score ?
71
PDB code
7aud
Structure name
structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Structure deposition date
2020-11-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
90
Peptide accession
P54132
Residue number A
895
Residue number B
901
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 895 of RecQ-like DNA helicase BLM
Cysteine 901 of RecQ-like DNA helicase BLM
4cdg B 1036 B 1066
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1036 and 1066.
Details
Redox score ?
65
PDB code
4cdg
Structure name
crystal structure of the bloom's syndrome helicase blm in complex with nanobody
Structure deposition date
2013-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
13
% buried
56
Peptide accession
P54132
Residue number A
1036
Residue number B
1066
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1036 of RecQ-like DNA helicase BLM
Cysteine 1066 of RecQ-like DNA helicase BLM
7aud A 1063 A 1067
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1063 and 1067.
Details
Redox score ?
63
PDB code
7aud
Structure name
structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Structure deposition date
2020-11-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
5
% buried
81
Peptide accession
P54132
Residue number A
1063
Residue number B
1067
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1063 of RecQ-like DNA helicase BLM
Cysteine 1067 of RecQ-like DNA helicase BLM
7auc A 1066 A 1067
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1066 and 1067. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7auc
Structure name
crystal structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Structure deposition date
2020-11-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
20
Peptide accession
P54132
Residue number A
1066
Residue number B
1067
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1066 of RecQ-like DNA helicase BLM
Cysteine 1067 of RecQ-like DNA helicase BLM
4o3m A 895 A 944
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 895 and 944. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
4o3m
Structure name
ternary complex of bloom's syndrome helicase
Structure deposition date
2013-12-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide accession
P54132
Residue number A
895
Residue number B
944
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 895 of RecQ-like DNA helicase BLM
Cysteine 944 of RecQ-like DNA helicase BLM
7aud F 901 F 944
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 901 and 944. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7aud
Structure name
structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Structure deposition date
2020-11-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
86
Peptide accession
P54132
Residue number A
901
Residue number B
944
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 901 of RecQ-like DNA helicase BLM
Cysteine 944 of RecQ-like DNA helicase BLM
7aud A 1055 A 1067
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1055 and 1067. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
7aud
Structure name
structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Structure deposition date
2020-11-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
nan
Peptide accession
P54132
Residue number A
1055
Residue number B
1067
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1055 of RecQ-like DNA helicase BLM
Cysteine 1067 of RecQ-like DNA helicase BLM
4cdg B 1055 B 1066
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1055 and 1066. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4cdg
Structure name
crystal structure of the bloom's syndrome helicase blm in complex with nanobody
Structure deposition date
2013-10-31
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
22
% buried
nan
Peptide accession
P54132
Residue number A
1055
Residue number B
1066
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1055 of RecQ-like DNA helicase BLM
Cysteine 1066 of RecQ-like DNA helicase BLM
7aud C 878 C 895
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 878 and 895. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7aud
Structure name
structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Structure deposition date
2020-11-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
98
Peptide accession
P54132
Residue number A
878
Residue number B
895
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 878 of RecQ-like DNA helicase BLM
Cysteine 895 of RecQ-like DNA helicase BLM
4cgz A 940 A 944
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 940 and 944. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
4cgz
Structure name
crystal structure of the bloom's syndrome helicase blm in complex with dna
Structure deposition date
2013-11-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
91
Peptide accession
P54132
Residue number A
940
Residue number B
944
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 940 of RecQ-like DNA helicase BLM
Cysteine 944 of RecQ-like DNA helicase BLM
2rrd A 24 A 32
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1218 and 1226 (24 and 32 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
2rrd
Structure name
structure of hrdc domain from human bloom syndrome protein, blm
Structure deposition date
2010-07-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
64
Peptide accession
P54132
Residue number A
1218
Residue number B
1226
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1218 of RecQ-like DNA helicase BLM
Cysteine 1226 of RecQ-like DNA helicase BLM
7aud A 685 A 698
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 685 and 698. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7aud
Structure name
structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Structure deposition date
2020-11-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
98
Peptide accession
P54132
Residue number A
685
Residue number B
698
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 685 of RecQ-like DNA helicase BLM
Cysteine 698 of RecQ-like DNA helicase BLM
7aud A 1036 A 1067
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 1036 and 1067. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7aud
Structure name
structure of an engineered helicase domain construct for human bloom syndrome protein (blm)
Structure deposition date
2020-11-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
76
Peptide accession
P54132
Residue number A
1036
Residue number B
1067
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 1036 of RecQ-like DNA helicase BLM
Cysteine 1067 of RecQ-like DNA helicase BLM
4cgz A 878 A 944
A redox-regulated disulphide may form within RecQ-like DNA helicase BLM between cysteines 878 and 944. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
4cgz
Structure name
crystal structure of the bloom's syndrome helicase blm in complex with dna
Structure deposition date
2013-11-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
13
% buried
100
Peptide accession
P54132
Residue number A
878
Residue number B
944
Peptide name
RecQ-like DNA helicase BLM
Ligandability
Cysteine 878 of RecQ-like DNA helicase BLM
Cysteine 944 of RecQ-like DNA helicase BLM
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