ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Mismatch repair endonuclease PMS2

Intermolecular
Cysteine 216 and cysteine 216
Cysteine 216 and cysteine 202
Intramolecular
Cysteine 252 and cysteine 259
Cysteine 192 and cysteine 216
Cysteine 192 and cysteine 202
A redox-regulated disulphide may form between two units of Mismatch repair endonuclease PMS2 at cysteines 216 and 216. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
7rci
Structure name
crystal structure of a pms2 vus with substrate
Structure deposition date
2021-07-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide A name
Mismatch repair endonuclease PMS2
Peptide B name
Mismatch repair endonuclease PMS2
Peptide A accession
P54278
Peptide B accession
P54278
Peptide A residue number
216
Peptide B residue number
216

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Mismatch repair endonuclease PMS2 at cysteines 216 and 202. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7rcb
Structure name
crystal structure of a pms2 vus
Structure deposition date
2021-07-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
90
Minimum pKa ?
11
% buried
100
Peptide A name
Mismatch repair endonuclease PMS2
Peptide B name
Mismatch repair endonuclease PMS2
Peptide A accession
P54278
Peptide B accession
P54278
Peptide A residue number
216
Peptide B residue number
202

Ligandability

Cysteine 216 of Mismatch repair endonuclease PMS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Mismatch repair endonuclease PMS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mismatch repair endonuclease PMS2 between cysteines 252 and 259. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
1ea6
Structure name
n-terminal 40kda fragment of nhpms2 complexed with adp
Structure deposition date
2001-07-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
2
Peptide accession
P54278
Residue number A
252
Residue number B
259
Peptide name
Mismatch repair endonuclease PMS2

Ligandability

Cysteine 252 of Mismatch repair endonuclease PMS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 259 of Mismatch repair endonuclease PMS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mismatch repair endonuclease PMS2 between cysteines 192 and 216. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
1ea6
Structure name
n-terminal 40kda fragment of nhpms2 complexed with adp
Structure deposition date
2001-07-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
9
% buried
100
Peptide accession
P54278
Residue number A
192
Residue number B
216
Peptide name
Mismatch repair endonuclease PMS2

Ligandability

Cysteine 192 of Mismatch repair endonuclease PMS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Mismatch repair endonuclease PMS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mismatch repair endonuclease PMS2 between cysteines 192 and 202. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
1h7u
Structure name
hpms2-atpgs
Structure deposition date
2001-07-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
P54278
Residue number A
192
Residue number B
202
Peptide name
Mismatch repair endonuclease PMS2

Ligandability

Cysteine 192 of Mismatch repair endonuclease PMS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of Mismatch repair endonuclease PMS2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: