ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Voltage-dependent calcium channel subunit alpha-2/delta-1

Intramolecular
Cysteine 1002 and cysteine 1027
Cysteine 667 and cysteine 697
Cysteine 406 and cysteine 1062
Cysteine 999 and cysteine 1029
Cysteine 907 and cysteine 977
Cysteine 356 and cysteine 1062
Cysteine 404 and cysteine 1071
Cysteine 844 and cysteine 853
Cysteine 303 and cysteine 1044
Cysteine 996 and cysteine 1024
More...
Cysteine 996 and cysteine 999
Cysteine 1024 and cysteine 1026
Cysteine 999 and cysteine 1026
A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 1002 and 1027.

Details

Redox score ?
88
PDB code
7jpk
Structure name
rabbit cav1
Structure deposition date
2020-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13806
Residue number A
1002
Residue number B
1027
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 1002 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1027 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 667 and 697.

Details

Redox score ?
87
PDB code
8e5a
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54289
Residue number A
667
Residue number B
697
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 667 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 697 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 406 and 1062.

Details

Redox score ?
87
PDB code
3jbr
Structure name
cryo-em structure of the rabbit voltage-gated calcium channel cav1
Structure deposition date
2015-09-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13806
Residue number A
406
Residue number B
1062
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 406 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1062 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 999 and 1029.

Details

Redox score ?
86
PDB code
5gjw
Structure name
structure of the mammalian voltage-gated calcium channel cav1
Structure deposition date
2016-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13806
Residue number A
999
Residue number B
1029
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 999 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1029 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 907 and 977.

Details

Redox score ?
86
PDB code
8e58
Structure name
rabbit l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13806
Residue number A
907
Residue number B
977
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 907 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 977 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 356 and 1062.

Details

Redox score ?
85
PDB code
7jpx
Structure name
rabbit cav1
Structure deposition date
2020-08-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13806
Residue number A
356
Residue number B
1062
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 356 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1062 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 404 and 1071.

Details

Redox score ?
85
PDB code
8e5b
Structure name
human l-type voltage-gated calcium channel cav1
Structure deposition date
2022-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54289
Residue number A
404
Residue number B
1071
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 404 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1071 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 844 and 853.

Details

Redox score ?
83
PDB code
7jpx
Structure name
rabbit cav1
Structure deposition date
2020-08-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P13806
Residue number A
844
Residue number B
853
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 844 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 853 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 303 and 1044.

Details

Redox score ?
82
PDB code
7vfs
Structure name
human n-type voltage gated calcium channel cav2
Structure deposition date
2021-09-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54289
Residue number A
303
Residue number B
1044
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 303 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1044 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 996 and 1024.

Details

Redox score ?
79
PDB code
7miy
Structure name
human n-type voltage-gated calcium channel cav2
Structure deposition date
2021-04-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54289
Residue number A
996
Residue number B
1024
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 996 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1024 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 996 and 999.

Details

Redox score ?
79
PDB code
7miy
Structure name
human n-type voltage-gated calcium channel cav2
Structure deposition date
2021-04-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
36
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54289
Residue number A
996
Residue number B
999
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 996 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 999 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 1024 and 1026.

Details

Redox score ?
77
PDB code
7miy
Structure name
human n-type voltage-gated calcium channel cav2
Structure deposition date
2021-04-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54289
Residue number A
1024
Residue number B
1026
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 1024 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1026 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Voltage-dependent calcium channel subunit alpha-2/delta-1 between cysteines 999 and 1026.

Details

Redox score ?
61
PDB code
7xlq
Structure name
structure of human r-type voltage-gated cav2
Structure deposition date
2022-04-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54289
Residue number A
999
Residue number B
1026
Peptide name
Voltage-dependent calcium channel subunit alpha-2/delta-1

Ligandability

Cysteine 999 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1026 of Voltage-dependent calcium channel subunit alpha-2/delta-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: