ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Inactive pancreatic lipase-related protein 1

Intramolecular
Cysteine 303 and cysteine 314
Cysteine 317 and cysteine 322
Cysteine 451 and cysteine 467
Cysteine 255 and cysteine 279
Cysteine 21 and cysteine 27
Cysteine 109 and cysteine 120
Cysteine 109 and cysteine 122
Cysteine 120 and cysteine 122
A redox-regulated disulphide may form within Inactive pancreatic lipase-related protein 1 between cysteines 303 and 314.

Details

Redox score ?
87
PDB code
2ppl
Structure name
human pancreatic lipase-related protein 1
Structure deposition date
2007-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54315
Residue number A
303
Residue number B
314
Peptide name
Inactive pancreatic lipase-related protein 1

Ligandability

Cysteine 303 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 314 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive pancreatic lipase-related protein 1 between cysteines 317 and 322.

Details

Redox score ?
85
PDB code
2ppl
Structure name
human pancreatic lipase-related protein 1
Structure deposition date
2007-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54315
Residue number A
317
Residue number B
322
Peptide name
Inactive pancreatic lipase-related protein 1

Ligandability

Cysteine 317 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive pancreatic lipase-related protein 1 between cysteines 451 and 467.

Details

Redox score ?
84
PDB code
2ppl
Structure name
human pancreatic lipase-related protein 1
Structure deposition date
2007-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54315
Residue number A
451
Residue number B
467
Peptide name
Inactive pancreatic lipase-related protein 1

Ligandability

Cysteine 451 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 467 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive pancreatic lipase-related protein 1 between cysteines 255 and 279.

Details

Redox score ?
83
PDB code
2ppl
Structure name
human pancreatic lipase-related protein 1
Structure deposition date
2007-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54315
Residue number A
255
Residue number B
279
Peptide name
Inactive pancreatic lipase-related protein 1

Ligandability

Cysteine 255 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive pancreatic lipase-related protein 1 between cysteines 21 and 27.

Details

Redox score ?
83
PDB code
2ppl
Structure name
human pancreatic lipase-related protein 1
Structure deposition date
2007-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54315
Residue number A
21
Residue number B
27
Peptide name
Inactive pancreatic lipase-related protein 1

Ligandability

Cysteine 21 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive pancreatic lipase-related protein 1 between cysteines 109 and 120.

Details

Redox score ?
80
PDB code
2ppl
Structure name
human pancreatic lipase-related protein 1
Structure deposition date
2007-04-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54315
Residue number A
109
Residue number B
120
Peptide name
Inactive pancreatic lipase-related protein 1

Ligandability

Cysteine 109 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive pancreatic lipase-related protein 1 between cysteines 109 and 122.

Details

Redox score ?
67
PDB code
2ppl
Structure name
human pancreatic lipase-related protein 1
Structure deposition date
2007-04-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
nan
Peptide accession
P54315
Residue number A
109
Residue number B
122
Peptide name
Inactive pancreatic lipase-related protein 1

Ligandability

Cysteine 109 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Inactive pancreatic lipase-related protein 1 between cysteines 120 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2ppl
Structure name
human pancreatic lipase-related protein 1
Structure deposition date
2007-04-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
nan
Peptide accession
P54315
Residue number A
120
Residue number B
122
Peptide name
Inactive pancreatic lipase-related protein 1

Ligandability

Cysteine 120 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Inactive pancreatic lipase-related protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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