ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pancreatic lipase-related protein 2

Intramolecular
Cysteine 304 and cysteine 315
Cysteine 453 and cysteine 469
Cysteine 318 and cysteine 323
Cysteine 21 and cysteine 27
Cysteine 255 and cysteine 279
Cysteine 109 and cysteine 120
Cysteine 109 and cysteine 122
Cysteine 120 and cysteine 122
Cysteine 315 and cysteine 323
Cysteine 315 and cysteine 318
A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 304 and 315.

Details

Redox score ?
86
PDB code
2oxe
Structure name
structure of the human pancreatic lipase-related protein 2
Structure deposition date
2007-02-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54317
Residue number A
304
Residue number B
315
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 304 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 453 and 469 (434 and 450 respectively in this structure).

Details

Redox score ?
85
PDB code
2pvs
Structure name
structure of human pancreatic lipase related protein 2 mutant n336q
Structure deposition date
2007-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54317
Residue number A
453
Residue number B
469
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 453 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 469 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 318 and 323 (299 and 304 respectively in this structure).

Details

Redox score ?
84
PDB code
2pvs
Structure name
structure of human pancreatic lipase related protein 2 mutant n336q
Structure deposition date
2007-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54317
Residue number A
318
Residue number B
323
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 318 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 21 and 27 (2 and 8 respectively in this structure).

Details

Redox score ?
84
PDB code
2pvs
Structure name
structure of human pancreatic lipase related protein 2 mutant n336q
Structure deposition date
2007-05-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54317
Residue number A
21
Residue number B
27
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 21 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 255 and 279 (237 and 261 respectively in this structure).

Details

Redox score ?
84
PDB code
1bu8
Structure name
rat pancreatic lipase related protein 2
Structure deposition date
1998-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54318
Residue number A
255
Residue number B
279
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 255 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 109 and 120.

Details

Redox score ?
79
PDB code
2oxe
Structure name
structure of the human pancreatic lipase-related protein 2
Structure deposition date
2007-02-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54317
Residue number A
109
Residue number B
120
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 109 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 109 and 122.

Details

Redox score ?
62
PDB code
2oxe
Structure name
structure of the human pancreatic lipase-related protein 2
Structure deposition date
2007-02-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
nan
Peptide accession
P54317
Residue number A
109
Residue number B
122
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 109 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 120 and 122 (101 and 103 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
2pvs
Structure name
structure of human pancreatic lipase related protein 2 mutant n336q
Structure deposition date
2007-05-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
94
Minimum pKa ?
13
% buried
nan
Peptide accession
P54317
Residue number A
120
Residue number B
122
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 120 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 315 and 323 (296 and 304 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2pvs
Structure name
structure of human pancreatic lipase related protein 2 mutant n336q
Structure deposition date
2007-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54317
Residue number A
315
Residue number B
323
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 315 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pancreatic lipase-related protein 2 between cysteines 315 and 318 (296 and 299 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2pvs
Structure name
structure of human pancreatic lipase related protein 2 mutant n336q
Structure deposition date
2007-05-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54317
Residue number A
315
Residue number B
318
Peptide name
Pancreatic lipase-related protein 2

Ligandability

Cysteine 315 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Pancreatic lipase-related protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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