ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Branched-chain-amino-acid aminotransferase, cytosolic

Intramolecular
Cysteine 335 and cysteine 338
A redox-regulated disulphide may form within Branched-chain-amino-acid aminotransferase, cytosolic between cysteines 335 and 338. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7nxn
Structure name
crystal structure of human cytosolic branched-chain aminotransferase (bcat1) in complex with plp and small molecule inhibitor compound 21(5-f)
Structure deposition date
2021-03-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
98
Peptide accession
P54687
Residue number A
335
Residue number B
338
Peptide name
Branched-chain-amino-acid aminotransferase, cytosolic

Ligandability

Cysteine 335 of Branched-chain-amino-acid aminotransferase, cytosolic

Cysteine 338 of Branched-chain-amino-acid aminotransferase, cytosolic

If this tool was useful for finding a disulphide, please cite: