a tool for identifying drug-targetable redox-active disulphides

Galactocerebrosidase

Intramolecular

Cysteine 287 and cysteine 394 L

A redox-regulated disulphide may form within Galactocerebrosidase between cysteines 287 and 394 (271 and 378 respectively in this structure).

Details

Redox score ?

79

PDB code

Structure name

mouse galactocerebrosidase in complex with saposin a

Structure deposition date

2017-05-09

Thiol separation (Å)

2

Half-sphere exposure sum ?

89

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

287

Residue number B

394

Peptide name

Galactocerebrosidase

Ligandability

Cysteine 287 of Galactocerebrosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 394 of Galactocerebrosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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