Growth arrest-specific protein 1
Intramolecular
Cysteine 166 and cysteine 222
Cysteine 199 and cysteine 243
Cysteine 105 and cysteine 146
Cysteine 190 and cysteine 203
Cysteine 173 and cysteine 179
Cysteine 48 and cysteine 128
Cysteine 130 and cysteine 136
Cysteine 72 and cysteine 109
Cysteine 224 and cysteine 232
Cysteine 55 and cysteine 61
More...Cysteine 166 and cysteine 232
Cysteine 203 and cysteine 243
Cysteine 166 and cysteine 224
Cysteine 109 and cysteine 146
Cysteine 128 and cysteine 130
Cysteine 48 and cysteine 136
Cysteine 48 and cysteine 130
Cysteine 199 and cysteine 203
Cysteine 128 and cysteine 136
Cysteine 105 and cysteine 109
Cysteine 222 and cysteine 232
Cysteine 190 and cysteine 243
Cysteine 72 and cysteine 146
Cysteine 222 and cysteine 224
Cysteine 72 and cysteine 105
Cysteine 190 and cysteine 199
7rhq G 166 G 222
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 166 and 222.
Details
Redox score ?
91
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
166
Residue number B
222
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 166 of Growth arrest-specific protein 1
Cysteine 222 of Growth arrest-specific protein 1
7rhq G 199 G 243
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 199 and 243.
Details
Redox score ?
89
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
199
Residue number B
243
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 199 of Growth arrest-specific protein 1
Cysteine 243 of Growth arrest-specific protein 1
7rhq G 105 G 146
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 105 and 146.
Details
Redox score ?
87
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
105
Residue number B
146
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 105 of Growth arrest-specific protein 1
Cysteine 146 of Growth arrest-specific protein 1
7rhq G 190 G 203
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 190 and 203.
Details
Redox score ?
86
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
190
Residue number B
203
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 190 of Growth arrest-specific protein 1
Cysteine 203 of Growth arrest-specific protein 1
7rhq G 173 G 179
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 173 and 179.
Details
Redox score ?
86
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
173
Residue number B
179
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 173 of Growth arrest-specific protein 1
Cysteine 179 of Growth arrest-specific protein 1
7rhq G 48 G 128
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 48 and 128.
Details
Redox score ?
86
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
48
Residue number B
128
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 48 of Growth arrest-specific protein 1
Cysteine 128 of Growth arrest-specific protein 1
7rhq G 130 G 136
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 130 and 136.
Details
Redox score ?
86
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
130
Residue number B
136
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 130 of Growth arrest-specific protein 1
Cysteine 136 of Growth arrest-specific protein 1
7rhq G 72 G 109
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 72 and 109.
Details
Redox score ?
84
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
72
Residue number B
109
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 72 of Growth arrest-specific protein 1
Cysteine 109 of Growth arrest-specific protein 1
7rhq G 224 G 232
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 224 and 232.
Details
Redox score ?
84
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
224
Residue number B
232
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 224 of Growth arrest-specific protein 1
Cysteine 232 of Growth arrest-specific protein 1
7rhq G 55 G 61
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 55 and 61.
Details
Redox score ?
82
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
55
Residue number B
61
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 55 of Growth arrest-specific protein 1
Cysteine 61 of Growth arrest-specific protein 1
7rhq G 166 G 232
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 166 and 232.
Details
Redox score ?
76
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
166
Residue number B
232
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 166 of Growth arrest-specific protein 1
Cysteine 232 of Growth arrest-specific protein 1
7rhq G 203 G 243
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 203 and 243.
Details
Redox score ?
75
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
203
Residue number B
243
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 203 of Growth arrest-specific protein 1
Cysteine 243 of Growth arrest-specific protein 1
7rhq G 166 G 224
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 166 and 224.
Details
Redox score ?
74
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
166
Residue number B
224
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 166 of Growth arrest-specific protein 1
Cysteine 224 of Growth arrest-specific protein 1
7rhq G 109 G 146
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 109 and 146.
Details
Redox score ?
72
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
109
Residue number B
146
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 109 of Growth arrest-specific protein 1
Cysteine 146 of Growth arrest-specific protein 1
7rhq G 128 G 130
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 128 and 130.
Details
Redox score ?
69
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
128
Residue number B
130
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 128 of Growth arrest-specific protein 1
Cysteine 130 of Growth arrest-specific protein 1
7rhq G 48 G 136
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 48 and 136.
Details
Redox score ?
68
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
48
Residue number B
136
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 48 of Growth arrest-specific protein 1
Cysteine 136 of Growth arrest-specific protein 1
7rhq G 48 G 130
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 48 and 130.
Details
Redox score ?
68
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
48
Residue number B
130
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 48 of Growth arrest-specific protein 1
Cysteine 130 of Growth arrest-specific protein 1
7rhq G 199 G 203
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 199 and 203.
Details
Redox score ?
66
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
199
Residue number B
203
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 199 of Growth arrest-specific protein 1
Cysteine 203 of Growth arrest-specific protein 1
7rhq G 128 G 136
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 128 and 136.
Details
Redox score ?
66
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
128
Residue number B
136
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 128 of Growth arrest-specific protein 1
Cysteine 136 of Growth arrest-specific protein 1
7rhq G 105 G 109
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 105 and 109.
Details
Redox score ?
65
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
105
Residue number B
109
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 105 of Growth arrest-specific protein 1
Cysteine 109 of Growth arrest-specific protein 1
7rhq G 222 G 232
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 222 and 232.
Details
Redox score ?
62
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
222
Residue number B
232
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 222 of Growth arrest-specific protein 1
Cysteine 232 of Growth arrest-specific protein 1
7rhq G 190 G 243
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 190 and 243.
Details
Redox score ?
62
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
190
Residue number B
243
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 190 of Growth arrest-specific protein 1
Cysteine 243 of Growth arrest-specific protein 1
7rhq G 72 G 146
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 72 and 146.
Details
Redox score ?
62
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
72
Residue number B
146
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 72 of Growth arrest-specific protein 1
Cysteine 146 of Growth arrest-specific protein 1
7rhq G 222 G 224
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 222 and 224.
Details
Redox score ?
62
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
222
Residue number B
224
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 222 of Growth arrest-specific protein 1
Cysteine 224 of Growth arrest-specific protein 1
7rhq G 72 G 105
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 72 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
72
Residue number B
105
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 72 of Growth arrest-specific protein 1
Cysteine 105 of Growth arrest-specific protein 1
7rhq G 190 G 199
A redox-regulated disulphide may form within Growth arrest-specific protein 1 between cysteines 190 and 199. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
7rhq
Structure name
cryo-em structure of xenopus patched-1 in complex with gas1 and sonic hedgehog
Structure deposition date
2021-07-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P54826
Residue number A
190
Residue number B
199
Peptide name
Growth arrest-specific protein 1
Ligandability
Cysteine 190 of Growth arrest-specific protein 1
Cysteine 199 of Growth arrest-specific protein 1
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