ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tyrosine-protein phosphatase non-receptor type 5

Intramolecular
Cysteine 512 and cysteine 513
Cysteine 384 and cysteine 472
Cysteine 472 and cysteine 481
A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 5 between cysteines 512 and 513 (488 and 489 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2cjz
Structure name
crystal structure of the c472s mutant of human protein tyrosine phosphatase ptpn5 (step, striatum enriched phosphatase) in complex with phosphotyrosine
Structure deposition date
2006-04-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
96
Peptide accession
P54829
Residue number A
512
Residue number B
513
Peptide name
Tyrosine-protein phosphatase non-receptor type 5

Ligandability

Cysteine 512 of Tyrosine-protein phosphatase non-receptor type 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 513 of Tyrosine-protein phosphatase non-receptor type 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 5 between cysteines 384 and 472. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6h8s
Structure name
crystal structure of the mouse protein tyrosine phosphatase ptpn5 (step) in complex with compound bi-0314
Structure deposition date
2018-08-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
8
% buried
98
Peptide accession
P54830
Residue number A
384
Residue number B
472
Peptide name
Tyrosine-protein phosphatase non-receptor type 5

Ligandability

Cysteine 384 of Tyrosine-protein phosphatase non-receptor type 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Tyrosine-protein phosphatase non-receptor type 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Tyrosine-protein phosphatase non-receptor type 5 between cysteines 472 and 481. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6h8s
Structure name
crystal structure of the mouse protein tyrosine phosphatase ptpn5 (step) in complex with compound bi-0314
Structure deposition date
2018-08-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
8
% buried
100
Peptide accession
P54830
Residue number A
472
Residue number B
481
Peptide name
Tyrosine-protein phosphatase non-receptor type 5

Ligandability

Cysteine 472 of Tyrosine-protein phosphatase non-receptor type 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 481 of Tyrosine-protein phosphatase non-receptor type 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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