ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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26S proteasome non-ATPase regulatory subunit 4

Intramolecular
Cysteine 9 and cysteine 58
Cysteine 58 and cysteine 87
A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 4 between cysteines 9 and 58. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5vhs
Structure name
conformational landscape of the p28-bound human proteasome regulatory particle
Structure deposition date
2017-04-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
90
Peptide accession
P55036
Residue number A
9
Residue number B
58
Peptide name
26S proteasome non-ATPase regulatory subunit 4

Ligandability

Cysteine 9 of 26S proteasome non-ATPase regulatory subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of 26S proteasome non-ATPase regulatory subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 26S proteasome non-ATPase regulatory subunit 4 between cysteines 58 and 87. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
5t0j
Structure name
structural basis for dynamic regulation of the human 26s proteasome
Structure deposition date
2016-08-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
69
Peptide accession
P55036
Residue number A
58
Residue number B
87
Peptide name
26S proteasome non-ATPase regulatory subunit 4

Ligandability

Cysteine 58 of 26S proteasome non-ATPase regulatory subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of 26S proteasome non-ATPase regulatory subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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