ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Fibroblast growth factor 8

Intramolecular
Cysteine 127 and cysteine 145
A redox-regulated disulphide may form within Fibroblast growth factor 8 between cysteines 127 and 145 (109 and 127 respectively in this structure).

Details

Redox score ?
79
PDB code
2fdb
Structure name
crystal structure of fibroblast growth factor (fgf)8b in complex with fgf receptor (fgfr) 2c
Structure deposition date
2005-12-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
83
Minimum pKa ?
8
% buried
55
Peptide accession
P55075
Residue number A
127
Residue number B
145
Peptide name
Fibroblast growth factor 8

Ligandability

Cysteine 127 of Fibroblast growth factor 8

Cysteine 145 of Fibroblast growth factor 8

If this tool was useful for finding a disulphide, please cite: