ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Peregrin

Intramolecular
Cysteine 276 and cysteine 279
Cysteine 276 and cysteine 304
Cysteine 293 and cysteine 320
Cysteine 293 and cysteine 296
Cysteine 293 and cysteine 317
Cysteine 386 and cysteine 389
Cysteine 296 and cysteine 320
Cysteine 330 and cysteine 333
Cysteine 276 and cysteine 277
Cysteine 296 and cysteine 317
More...
Cysteine 400 and cysteine 444
Cysteine 317 and cysteine 320
Cysteine 386 and cysteine 413
Cysteine 400 and cysteine 405
Cysteine 405 and cysteine 444
Cysteine 333 and cysteine 353
Cysteine 389 and cysteine 413
Cysteine 279 and cysteine 304
Cysteine 386 and cysteine 397
Cysteine 389 and cysteine 397
Cysteine 333 and cysteine 413
Cysteine 277 and cysteine 296
Cysteine 330 and cysteine 353
Cysteine 333 and cysteine 386
Cysteine 397 and cysteine 413
Cysteine 333 and cysteine 389
Cysteine 277 and cysteine 317
Cysteine 277 and cysteine 279
Cysteine 353 and cysteine 413
Cysteine 333 and cysteine 397
Cysteine 277 and cysteine 304
Cysteine 353 and cysteine 397
A redox-regulated disulphide may form within Peregrin between cysteines 276 and 279.

Details

Redox score ?
92
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
0
% buried
52
Peptide accession
P55201
Residue number A
276
Residue number B
279
Peptide name
Peregrin

Ligandability

Cysteine 276 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 276 and 304.

Details

Redox score ?
92
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
0
% buried
58
Peptide accession
P55201
Residue number A
276
Residue number B
304
Peptide name
Peregrin

Ligandability

Cysteine 276 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 293 and 320.

Details

Redox score ?
88
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
21
Peptide accession
P55201
Residue number A
293
Residue number B
320
Peptide name
Peregrin

Ligandability

Cysteine 293 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 320 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 293 and 296.

Details

Redox score ?
85
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
30
Peptide accession
P55201
Residue number A
293
Residue number B
296
Peptide name
Peregrin

Ligandability

Cysteine 293 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 293 and 317.

Details

Redox score ?
84
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
6
% buried
40
Peptide accession
P55201
Residue number A
293
Residue number B
317
Peptide name
Peregrin

Ligandability

Cysteine 293 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 386 and 389.

Details

Redox score ?
82
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
7
% buried
29
Peptide accession
P55201
Residue number A
386
Residue number B
389
Peptide name
Peregrin

Ligandability

Cysteine 386 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 389 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 296 and 320.

Details

Redox score ?
82
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
24
Peptide accession
P55201
Residue number A
296
Residue number B
320
Peptide name
Peregrin

Ligandability

Cysteine 296 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 320 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 330 and 333.

Details

Redox score ?
81
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
6
% buried
nan
Peptide accession
P55201
Residue number A
330
Residue number B
333
Peptide name
Peregrin

Ligandability

Cysteine 330 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 333 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 276 and 277.

Details

Redox score ?
80
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
0
% buried
67
Peptide accession
P55201
Residue number A
276
Residue number B
277
Peptide name
Peregrin

Ligandability

Cysteine 276 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 296 and 317.

Details

Redox score ?
79
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
43
Peptide accession
P55201
Residue number A
296
Residue number B
317
Peptide name
Peregrin

Ligandability

Cysteine 296 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 400 and 444.

Details

Redox score ?
79
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
12
Peptide accession
P55201
Residue number A
400
Residue number B
444
Peptide name
Peregrin

Ligandability

Cysteine 400 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 444 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 317 and 320.

Details

Redox score ?
78
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
34
Peptide accession
P55201
Residue number A
317
Residue number B
320
Peptide name
Peregrin

Ligandability

Cysteine 317 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 320 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 386 and 413.

Details

Redox score ?
78
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
42
Peptide accession
P55201
Residue number A
386
Residue number B
413
Peptide name
Peregrin

Ligandability

Cysteine 386 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 413 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 400 and 405.

Details

Redox score ?
76
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
400
Residue number B
405
Peptide name
Peregrin

Ligandability

Cysteine 400 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 405 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 405 and 444.

Details

Redox score ?
76
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
405
Residue number B
444
Peptide name
Peregrin

Ligandability

Cysteine 405 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 444 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 333 and 353.

Details

Redox score ?
75
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
6
% buried
87
Peptide accession
P55201
Residue number A
333
Residue number B
353
Peptide name
Peregrin

Ligandability

Cysteine 333 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 389 and 413.

Details

Redox score ?
71
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
389
Residue number B
413
Peptide name
Peregrin

Ligandability

Cysteine 389 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 413 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 279 and 304.

Details

Redox score ?
68
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
50
Peptide accession
P55201
Residue number A
279
Residue number B
304
Peptide name
Peregrin

Ligandability

Cysteine 279 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 386 and 397.

Details

Redox score ?
67
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
386
Residue number B
397
Peptide name
Peregrin

Ligandability

Cysteine 386 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 389 and 397. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
36
Peptide accession
P55201
Residue number A
389
Residue number B
397
Peptide name
Peregrin

Ligandability

Cysteine 389 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 333 and 413. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
333
Residue number B
413
Peptide name
Peregrin

Ligandability

Cysteine 333 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 413 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 277 and 296. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
54
Peptide accession
P55201
Residue number A
277
Residue number B
296
Peptide name
Peregrin

Ligandability

Cysteine 277 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 330 and 353. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
19
% buried
nan
Peptide accession
P55201
Residue number A
330
Residue number B
353
Peptide name
Peregrin

Ligandability

Cysteine 330 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 353 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 333 and 386. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
6
% buried
58
Peptide accession
P55201
Residue number A
333
Residue number B
386
Peptide name
Peregrin

Ligandability

Cysteine 333 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 386 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 397 and 413. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
397
Residue number B
413
Peptide name
Peregrin

Ligandability

Cysteine 397 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 413 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 333 and 389. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
333
Residue number B
389
Peptide name
Peregrin

Ligandability

Cysteine 333 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 389 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 277 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
277
Residue number B
317
Peptide name
Peregrin

Ligandability

Cysteine 277 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 277 and 279. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
277
Residue number B
279
Peptide name
Peregrin

Ligandability

Cysteine 277 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 353 and 413. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
353
Residue number B
413
Peptide name
Peregrin

Ligandability

Cysteine 353 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 413 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 333 and 397. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6u04
Structure name
crystal structure of human brpf1 pzp bound to histone h3 tail
Structure deposition date
2019-08-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55201
Residue number A
333
Residue number B
397
Peptide name
Peregrin

Ligandability

Cysteine 333 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 277 and 304. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
66
Peptide accession
P55201
Residue number A
277
Residue number B
304
Peptide name
Peregrin

Ligandability

Cysteine 277 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 304 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Peregrin between cysteines 353 and 397. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
5erc
Structure name
x-ray crystal structure of brpf1 pzp domain
Structure deposition date
2015-11-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
78
Peptide accession
P55201
Residue number A
353
Residue number B
397
Peptide name
Peregrin

Ligandability

Cysteine 353 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Peregrin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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