Caspase-6

Intermolecular

Intramolecular

A redox-regulated disulphide may form between two units of Caspase-6 at cysteines 277 and 277. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

3nkf

Structure name

crystal structure of human ligand-free mature caspase-6 with intersubunit linker attached

Structure deposition date

2010-06-18

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide A name

Caspase-6

Peptide B name

Caspase-6

Peptide A accession

P55212

Peptide B accession

P55212

Peptide A residue number

277

Peptide B residue number

277

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Caspase-6 between cysteines 68 and 87. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

3p45

Structure name

crystal structure of apo-caspase-6 at physiological ph

Structure deposition date

2010-10-06

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

P55212

Residue number A

Residue number B

Peptide name

Caspase-6

Ligandability

Cysteine 68 of Caspase-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Caspase-6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Caspase-6 between cysteines 209 and 277. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?