ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Pancreatic secretory granule membrane major glycoprotein GP2

Intermolecular
Cysteine 146 and cysteine 172
Cysteine 146 and cysteine 85
Cysteine 138 and cysteine 172
Intramolecular
Cysteine 48 and cysteine 59
Cysteine 63 and cysteine 157
Cysteine 107 and cysteine 145
Cysteine 85 and cysteine 172
Cysteine 138 and cysteine 146
Cysteine 113 and cysteine 177
Cysteine 145 and cysteine 146
More...
Cysteine 138 and cysteine 145
Cysteine 107 and cysteine 138
Cysteine 107 and cysteine 146
Cysteine 107 and cysteine 177
A redox-regulated disulphide may form between two units of Pancreatic secretory granule membrane major glycoprotein GP2 at cysteines 146 and 172. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7p6r
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form i)
Structure deposition date
2021-07-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
Pancreatic secretory granule membrane major glycoprotein GP2
Peptide B name
Pancreatic secretory granule membrane major glycoprotein GP2
Peptide A accession
P55259
Peptide B accession
P55259
Peptide A residue number
146
Peptide B residue number
172

Ligandability

Cysteine 146 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 172 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form between two units of Pancreatic secretory granule membrane major glycoprotein GP2 at cysteines 146 and 85. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7p6r
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form i)
Structure deposition date
2021-07-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide A name
Pancreatic secretory granule membrane major glycoprotein GP2
Peptide B name
Pancreatic secretory granule membrane major glycoprotein GP2
Peptide A accession
P55259
Peptide B accession
P55259
Peptide A residue number
146
Peptide B residue number
85

Ligandability

Cysteine 146 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 85 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form between two units of Pancreatic secretory granule membrane major glycoprotein GP2 at cysteines 138 and 172. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7p6r
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form i)
Structure deposition date
2021-07-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide A name
Pancreatic secretory granule membrane major glycoprotein GP2
Peptide B name
Pancreatic secretory granule membrane major glycoprotein GP2
Peptide A accession
P55259
Peptide B accession
P55259
Peptide A residue number
138
Peptide B residue number
172

Ligandability

Cysteine 138 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 172 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 48 and 59.

Details

Redox score ?
87
PDB code
7p6r
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form i)
Structure deposition date
2021-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
31
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
48
Residue number B
59
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 48 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 59 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 63 and 157.

Details

Redox score ?
84
PDB code
7p6r
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form i)
Structure deposition date
2021-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
63
Residue number B
157
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 63 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 157 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 107 and 145.

Details

Redox score ?
84
PDB code
7p6r
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form i)
Structure deposition date
2021-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
107
Residue number B
145
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 107 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 145 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 85 and 172.

Details

Redox score ?
82
PDB code
7p6t
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form iii)
Structure deposition date
2021-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
85
Residue number B
172
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 85 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 172 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 138 and 146.

Details

Redox score ?
81
PDB code
7p6t
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form iii)
Structure deposition date
2021-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
138
Residue number B
146
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 138 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 146 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 113 and 177.

Details

Redox score ?
80
PDB code
7p6t
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form iii)
Structure deposition date
2021-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
113
Residue number B
177
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 113 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 177 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 145 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7p6s
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form ii)
Structure deposition date
2021-07-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
145
Residue number B
146
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 145 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 146 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 138 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7p6r
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form i)
Structure deposition date
2021-07-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
138
Residue number B
145
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 138 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 145 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 107 and 138. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7p6t
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form iii)
Structure deposition date
2021-07-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
107
Residue number B
138
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 107 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 138 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 107 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7p6r
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form i)
Structure deposition date
2021-07-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
107
Residue number B
146
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 107 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 146 of Pancreatic secretory granule membrane major glycoprotein GP2

A redox-regulated disulphide may form within Pancreatic secretory granule membrane major glycoprotein GP2 between cysteines 107 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7p6r
Structure name
crystal structure of the fimh-binding decoy module of human glycoprotein 2 (gp2) (crystal form i)
Structure deposition date
2021-07-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
P55259
Residue number A
107
Residue number B
177
Peptide name
Pancreatic secretory granule membrane major glycoprotein GP2

Ligandability

Cysteine 107 of Pancreatic secretory granule membrane major glycoprotein GP2

Cysteine 177 of Pancreatic secretory granule membrane major glycoprotein GP2

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