ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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NHP2-like protein 1

Intramolecular
Cysteine 93 and cysteine 102
Cysteine 30 and cysteine 93
Cysteine 30 and cysteine 102
A redox-regulated disulphide may form within NHP2-like protein 1 between cysteines 93 and 102.

Details

Redox score ?
66
PDB code
3siu
Structure name
structure of a hprp31-15
Structure deposition date
2011-06-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
8
% buried
100
Peptide accession
P55769
Residue number A
93
Residue number B
102
Peptide name
NHP2-like protein 1

Ligandability

Cysteine 93 of NHP2-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of NHP2-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NHP2-like protein 1 between cysteines 30 and 93.

Details

Redox score ?
63
PDB code
1e7k
Structure name
crystal structure of the spliceosomal 15
Structure deposition date
2000-08-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
8
% buried
74
Peptide accession
P55769
Residue number A
30
Residue number B
93
Peptide name
NHP2-like protein 1

Ligandability

Cysteine 30 of NHP2-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of NHP2-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NHP2-like protein 1 between cysteines 30 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
1e7k
Structure name
crystal structure of the spliceosomal 15
Structure deposition date
2000-08-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
74
Peptide accession
P55769
Residue number A
30
Residue number B
102
Peptide name
NHP2-like protein 1

Ligandability

Cysteine 30 of NHP2-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of NHP2-like protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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