ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GDNF family receptor alpha-1

Intramolecular
Cysteine 250 and cysteine 256
Cysteine 315 and cysteine 325
Cysteine 187 and cysteine 233
Cysteine 216 and cysteine 221
Cysteine 267 and cysteine 285
Cysteine 277 and cysteine 337
Cysteine 243 and cysteine 313
Cysteine 178 and cysteine 192
Cysteine 154 and cysteine 214
Cysteine 161 and cysteine 167
More...
Cysteine 154 and cysteine 216
Cysteine 192 and cysteine 233
Cysteine 154 and cysteine 221
Cysteine 243 and cysteine 325
Cysteine 285 and cysteine 337
Cysteine 214 and cysteine 216
Cysteine 243 and cysteine 315
Cysteine 267 and cysteine 337
Cysteine 214 and cysteine 221
Cysteine 178 and cysteine 233
Cysteine 187 and cysteine 192
Cysteine 277 and cysteine 285
Cysteine 313 and cysteine 325
Cysteine 313 and cysteine 315
Cysteine 178 and cysteine 187
Cysteine 267 and cysteine 277
A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 250 and 256.

Details

Redox score ?
86
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
250
Residue number B
256
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 250 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 256 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 315 and 325.

Details

Redox score ?
85
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
315
Residue number B
325
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 315 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 187 and 233.

Details

Redox score ?
85
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
187
Residue number B
233
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 187 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 216 and 221.

Details

Redox score ?
85
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
216
Residue number B
221
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 216 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 267 and 285.

Details

Redox score ?
85
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
267
Residue number B
285
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 267 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 285 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 277 and 337.

Details

Redox score ?
84
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
277
Residue number B
337
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 277 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 337 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 243 and 313.

Details

Redox score ?
84
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
243
Residue number B
313
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 243 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 313 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 178 and 192.

Details

Redox score ?
83
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
178
Residue number B
192
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 178 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 154 and 214.

Details

Redox score ?
83
PDB code
2v5e
Structure name
the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding
Structure deposition date
2008-10-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62997
Residue number A
154
Residue number B
214
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 154 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 161 and 167.

Details

Redox score ?
81
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
161
Residue number B
167
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 161 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 154 and 216.

Details

Redox score ?
78
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62997
Residue number A
154
Residue number B
216
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 154 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 192 and 233.

Details

Redox score ?
76
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62997
Residue number A
192
Residue number B
233
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 192 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 154 and 221.

Details

Redox score ?
75
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62997
Residue number A
154
Residue number B
221
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 154 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 243 and 325.

Details

Redox score ?
73
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
243
Residue number B
325
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 243 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 285 and 337.

Details

Redox score ?
71
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62997
Residue number A
285
Residue number B
337
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 285 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 337 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 214 and 216.

Details

Redox score ?
68
PDB code
3fub
Structure name
crystal structure of gdnf-gfralpha1 complex
Structure deposition date
2009-01-14
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62997
Residue number A
214
Residue number B
216
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 214 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 243 and 315.

Details

Redox score ?
68
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
243
Residue number B
315
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 243 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 267 and 337.

Details

Redox score ?
66
PDB code
1q8d
Structure name
the crystal structure of gdnf family co-receptor alpha 1 domain 3
Structure deposition date
2003-08-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62997
Residue number A
267
Residue number B
337
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 267 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 337 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 214 and 221.

Details

Redox score ?
66
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
214
Residue number B
221
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 214 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 178 and 233.

Details

Redox score ?
65
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
178
Residue number B
233
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 178 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 233 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 187 and 192.

Details

Redox score ?
63
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
187
Residue number B
192
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 187 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 192 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 277 and 285.

Details

Redox score ?
63
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
277
Residue number B
285
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 277 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 285 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 313 and 325.

Details

Redox score ?
61
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
313
Residue number B
325
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 313 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 313 and 315. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
313
Residue number B
315
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 313 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 315 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 178 and 187. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
178
Residue number B
187
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 178 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within GDNF family receptor alpha-1 between cysteines 267 and 277. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6q2n
Structure name
cryo-em structure of ret/gfra1/gdnf extracellular complex
Structure deposition date
2019-08-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56159
Residue number A
267
Residue number B
277
Peptide name
GDNF family receptor alpha-1

Ligandability

Cysteine 267 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of GDNF family receptor alpha-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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