ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Cx9C motif-containing protein 4

Intramolecular
Cysteine 39 and cysteine 50
Cysteine 17 and cysteine 28
Cysteine 7 and cysteine 38
Cysteine 7 and cysteine 50
Cysteine 7 and cysteine 39
Cysteine 38 and cysteine 39
Cysteine 38 and cysteine 50
A redox-regulated disulphide may form within Cx9C motif-containing protein 4 between cysteines 39 and 50.

Details

Redox score ?
86
PDB code
2hp8
Structure name
solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha-helical assembly motif, nmr, 30 structures
Structure deposition date
1997-08-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56277
Residue number A
39
Residue number B
50
Peptide name
Cx9C motif-containing protein 4

Ligandability

Cysteine 39 of Cx9C motif-containing protein 4

Cysteine 50 of Cx9C motif-containing protein 4

A redox-regulated disulphide may form within Cx9C motif-containing protein 4 between cysteines 17 and 28.

Details

Redox score ?
86
PDB code
2hp8
Structure name
solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha-helical assembly motif, nmr, 30 structures
Structure deposition date
1997-08-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56277
Residue number A
17
Residue number B
28
Peptide name
Cx9C motif-containing protein 4

Ligandability

Cysteine 17 of Cx9C motif-containing protein 4

Cysteine 28 of Cx9C motif-containing protein 4

A redox-regulated disulphide may form within Cx9C motif-containing protein 4 between cysteines 7 and 38.

Details

Redox score ?
84
PDB code
1hp8
Structure name
solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha-helical assembly motif, nmr, minimized average structure
Structure deposition date
1997-08-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56277
Residue number A
7
Residue number B
38
Peptide name
Cx9C motif-containing protein 4

Ligandability

Cysteine 7 of Cx9C motif-containing protein 4

Cysteine 38 of Cx9C motif-containing protein 4

A redox-regulated disulphide may form within Cx9C motif-containing protein 4 between cysteines 7 and 50.

Details

Redox score ?
66
PDB code
2hp8
Structure name
solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha-helical assembly motif, nmr, 30 structures
Structure deposition date
1997-08-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56277
Residue number A
7
Residue number B
50
Peptide name
Cx9C motif-containing protein 4

Ligandability

Cysteine 7 of Cx9C motif-containing protein 4

Cysteine 50 of Cx9C motif-containing protein 4

A redox-regulated disulphide may form within Cx9C motif-containing protein 4 between cysteines 7 and 39.

Details

Redox score ?
66
PDB code
1hp8
Structure name
solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha-helical assembly motif, nmr, minimized average structure
Structure deposition date
1997-08-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56277
Residue number A
7
Residue number B
39
Peptide name
Cx9C motif-containing protein 4

Ligandability

Cysteine 7 of Cx9C motif-containing protein 4

Cysteine 39 of Cx9C motif-containing protein 4

A redox-regulated disulphide may form within Cx9C motif-containing protein 4 between cysteines 38 and 39. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
1hp8
Structure name
solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha-helical assembly motif, nmr, minimized average structure
Structure deposition date
1997-08-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56277
Residue number A
38
Residue number B
39
Peptide name
Cx9C motif-containing protein 4

Ligandability

Cysteine 38 of Cx9C motif-containing protein 4

Cysteine 39 of Cx9C motif-containing protein 4

A redox-regulated disulphide may form within Cx9C motif-containing protein 4 between cysteines 38 and 50. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
1hp8
Structure name
solution structure of human p8-mtcp1, a cysteine-rich protein encoded by the mtcp1 oncogene,reveals a new alpha-helical assembly motif, nmr, minimized average structure
Structure deposition date
1997-08-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56277
Residue number A
38
Residue number B
50
Peptide name
Cx9C motif-containing protein 4

Ligandability

Cysteine 38 of Cx9C motif-containing protein 4

Cysteine 50 of Cx9C motif-containing protein 4

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