DNA polymerase epsilon subunit 2
Intramolecular
Cysteine 424 and cysteine 427
Cysteine 494 and cysteine 496 L
Cysteine 222 and cysteine 427
Cysteine 322 and cysteine 403
Cysteine 318 and cysteine 403
5vbn A 424 A 427
A redox-regulated disulphide may form within DNA polymerase epsilon subunit 2 between cysteines 424 and 427.
Details
Redox score ?
63
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
54
Peptide accession
P56282
Residue number A
424
Residue number B
427
Peptide name
DNA polymerase epsilon subunit 2
Ligandability
Cysteine 424 of DNA polymerase epsilon subunit 2
Cysteine 427 of DNA polymerase epsilon subunit 2
5vbn E 494 E 496
A redox-regulated disulphide may form within DNA polymerase epsilon subunit 2 between cysteines 494 and 496. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
99
Peptide accession
P56282
Residue number A
494
Residue number B
496
Peptide name
DNA polymerase epsilon subunit 2
Ligandability
Cysteine 494 of DNA polymerase epsilon subunit 2
Cysteine 496 of DNA polymerase epsilon subunit 2
5vbn A 222 A 427
A redox-regulated disulphide may form within DNA polymerase epsilon subunit 2 between cysteines 222 and 427. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
83
Peptide accession
P56282
Residue number A
222
Residue number B
427
Peptide name
DNA polymerase epsilon subunit 2
Ligandability
Cysteine 222 of DNA polymerase epsilon subunit 2
Cysteine 427 of DNA polymerase epsilon subunit 2
5vbn E 322 E 403
A redox-regulated disulphide may form within DNA polymerase epsilon subunit 2 between cysteines 322 and 403. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
100
Peptide accession
P56282
Residue number A
322
Residue number B
403
Peptide name
DNA polymerase epsilon subunit 2
Ligandability
Cysteine 322 of DNA polymerase epsilon subunit 2
Cysteine 403 of DNA polymerase epsilon subunit 2
5vbn E 318 E 403
A redox-regulated disulphide may form within DNA polymerase epsilon subunit 2 between cysteines 318 and 403. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
26
PDB code
5vbn
Structure name
crystal structure of human dna polymerase epsilon b-subunit in complex with c-terminal domain of catalytic subunit
Structure deposition date
2017-03-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
13
% buried
100
Peptide accession
P56282
Residue number A
318
Residue number B
403
Peptide name
DNA polymerase epsilon subunit 2
Ligandability
Cysteine 318 of DNA polymerase epsilon subunit 2
Cysteine 403 of DNA polymerase epsilon subunit 2
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