P2X purinoceptor 3
Intramolecular
Cysteine 247 and cysteine 256
Cysteine 116 and cysteine 137
Cysteine 122 and cysteine 147
Cysteine 203 and cysteine 213
Cysteine 107 and cysteine 153
Cysteine 116 and cysteine 122
Cysteine 122 and cysteine 137
Cysteine 116 and cysteine 147
Cysteine 137 and cysteine 147
6ah5 C 247 C 256
A redox-regulated disulphide may form within P2X purinoceptor 3 between cysteines 247 and 256.
Details
Redox score ?
87
PDB code
6ah5
Structure name
structure of human p2x3 receptor in complex with atp and mg2+ ion
Structure deposition date
2018-08-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56373
Residue number A
247
Residue number B
256
Peptide name
P2X purinoceptor 3
Ligandability
Cysteine 247 of P2X purinoceptor 3
Cysteine 256 of P2X purinoceptor 3
5svs A 116 A 137
A redox-regulated disulphide may form within P2X purinoceptor 3 between cysteines 116 and 137.
Details
Redox score ?
85
PDB code
5svs
Structure name
anomalous mn2+ signal reveals a divalent cation-binding site in the head domain of the atp-gated human p2x3 ion channel
Structure deposition date
2016-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56373
Residue number A
116
Residue number B
137
Peptide name
P2X purinoceptor 3
Ligandability
Cysteine 116 of P2X purinoceptor 3
Cysteine 137 of P2X purinoceptor 3
5svk A 122 A 147
A redox-regulated disulphide may form within P2X purinoceptor 3 between cysteines 122 and 147.
Details
Redox score ?
85
PDB code
5svk
Structure name
crystal structure of the atp-gated human p2x3 ion channel in the atp- bound, open state
Structure deposition date
2016-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56373
Residue number A
122
Residue number B
147
Peptide name
P2X purinoceptor 3
Ligandability
Cysteine 122 of P2X purinoceptor 3
Cysteine 147 of P2X purinoceptor 3
5svt A 203 A 213
A redox-regulated disulphide may form within P2X purinoceptor 3 between cysteines 203 and 213.
Details
Redox score ?
85
PDB code
5svt
Structure name
anomalous cs+ signal reveals the site of na+ ion entry to the channel pore of the human p2x3 ion channel through the extracellular fenestrations
Structure deposition date
2016-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56373
Residue number A
203
Residue number B
213
Peptide name
P2X purinoceptor 3
Ligandability
Cysteine 203 of P2X purinoceptor 3
Cysteine 213 of P2X purinoceptor 3
5svk B 107 B 153
A redox-regulated disulphide may form within P2X purinoceptor 3 between cysteines 107 and 153.
Details
Redox score ?
82
PDB code
5svk
Structure name
crystal structure of the atp-gated human p2x3 ion channel in the atp- bound, open state
Structure deposition date
2016-08-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56373
Residue number A
107
Residue number B
153
Peptide name
P2X purinoceptor 3
Ligandability
Cysteine 107 of P2X purinoceptor 3
Cysteine 153 of P2X purinoceptor 3
5svs A 116 A 122
A redox-regulated disulphide may form within P2X purinoceptor 3 between cysteines 116 and 122.
Details
Redox score ?
79
PDB code
5svs
Structure name
anomalous mn2+ signal reveals a divalent cation-binding site in the head domain of the atp-gated human p2x3 ion channel
Structure deposition date
2016-08-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56373
Residue number A
116
Residue number B
122
Peptide name
P2X purinoceptor 3
Ligandability
Cysteine 116 of P2X purinoceptor 3
Cysteine 122 of P2X purinoceptor 3
5svm B 122 B 137
A redox-regulated disulphide may form within P2X purinoceptor 3 between cysteines 122 and 137.
Details
Redox score ?
73
PDB code
5svm
Structure name
crystal structure of the atp-gated human p2x3 ion channel bound to agonist 2-methylthio-atp in the desensitized state
Structure deposition date
2016-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56373
Residue number A
122
Residue number B
137
Peptide name
P2X purinoceptor 3
Ligandability
Cysteine 122 of P2X purinoceptor 3
Cysteine 137 of P2X purinoceptor 3
5svm B 116 B 147
A redox-regulated disulphide may form within P2X purinoceptor 3 between cysteines 116 and 147.
Details
Redox score ?
70
PDB code
5svm
Structure name
crystal structure of the atp-gated human p2x3 ion channel bound to agonist 2-methylthio-atp in the desensitized state
Structure deposition date
2016-08-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56373
Residue number A
116
Residue number B
147
Peptide name
P2X purinoceptor 3
Ligandability
Cysteine 116 of P2X purinoceptor 3
Cysteine 147 of P2X purinoceptor 3
6ah5 B 137 B 147
A redox-regulated disulphide may form within P2X purinoceptor 3 between cysteines 137 and 147.
Details
Redox score ?
61
PDB code
6ah5
Structure name
structure of human p2x3 receptor in complex with atp and mg2+ ion
Structure deposition date
2018-08-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
P56373
Residue number A
137
Residue number B
147
Peptide name
P2X purinoceptor 3
Ligandability
Cysteine 137 of P2X purinoceptor 3
Cysteine 147 of P2X purinoceptor 3
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