ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Potassium voltage-gated channel subfamily KQT member 4

Intramolecular
Cysteine 156 and cysteine 157
Cysteine 157 and cysteine 158
Cysteine 156 and cysteine 158
A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily KQT member 4 between cysteines 156 and 157.

Details

Redox score ?
76
PDB code
7byl
Structure name
cryo-em structure of human kcnq4
Structure deposition date
2020-04-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
78
Peptide accession
P56696
Residue number A
156
Residue number B
157
Peptide name
Potassium voltage-gated channel subfamily KQT member 4

Ligandability

Cysteine 156 of Potassium voltage-gated channel subfamily KQT member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of Potassium voltage-gated channel subfamily KQT member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily KQT member 4 between cysteines 157 and 158.

Details

Redox score ?
60
PDB code
7byn
Structure name
cryo-em structure of human kcnq4 with linopirdine
Structure deposition date
2020-04-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
62
Peptide accession
P56696
Residue number A
157
Residue number B
158
Peptide name
Potassium voltage-gated channel subfamily KQT member 4

Ligandability

Cysteine 157 of Potassium voltage-gated channel subfamily KQT member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of Potassium voltage-gated channel subfamily KQT member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Potassium voltage-gated channel subfamily KQT member 4 between cysteines 156 and 158. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7bym
Structure name
cryo-em structure of human kcnq4 with retigabine
Structure deposition date
2020-04-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
60
Peptide accession
P56696
Residue number A
156
Residue number B
158
Peptide name
Potassium voltage-gated channel subfamily KQT member 4

Ligandability

Cysteine 156 of Potassium voltage-gated channel subfamily KQT member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of Potassium voltage-gated channel subfamily KQT member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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