a tool for identifying drug-targetable redox-active disulphides

Claudin-15

Intramolecular

Cysteine 52 and cysteine 62

A redox-regulated disulphide may form within Claudin-15 between cysteines 52 and 62.

Details

Redox score ?

87

PDB code

Structure name

crystal structure of mouse claudin-15

Structure deposition date

2014-03-26

Thiol separation (Å)

2

Half-sphere exposure sum ?

46

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

52

Residue number B

62

Peptide name

Claudin-15

Ligandability

Cysteine 52 of Claudin-15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Claudin-15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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