ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RWD domain-containing protein 2B

Intramolecular
Cysteine 145 and cysteine 150 L
Cysteine 105 and cysteine 145 L
Cysteine 105 and cysteine 150 L
A redox-regulated disulphide may form within RWD domain-containing protein 2B between cysteines 145 and 150 (119 and 124 respectively in this structure).

Details

Redox score ?
72
PDB code
2dax
Structure name
solution structure of the rwd domain of human protein c21orf6
Structure deposition date
2005-12-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
16
Peptide accession
P57060
Residue number A
145
Residue number B
150
Peptide name
RWD domain-containing protein 2B

Ligandability

Cysteine 145 of RWD domain-containing protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 150 of RWD domain-containing protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RWD domain-containing protein 2B between cysteines 105 and 145 (79 and 119 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
2dax
Structure name
solution structure of the rwd domain of human protein c21orf6
Structure deposition date
2005-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
54
Peptide accession
P57060
Residue number A
105
Residue number B
145
Peptide name
RWD domain-containing protein 2B

Ligandability

Cysteine 105 of RWD domain-containing protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of RWD domain-containing protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within RWD domain-containing protein 2B between cysteines 105 and 150 (79 and 124 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2dax
Structure name
solution structure of the rwd domain of human protein c21orf6
Structure deposition date
2005-12-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
58
Peptide accession
P57060
Residue number A
105
Residue number B
150
Peptide name
RWD domain-containing protein 2B

Ligandability

Cysteine 105 of RWD domain-containing protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 150 of RWD domain-containing protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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