ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-interacting serine/threonine-protein kinase 4

Intramolecular
Cysteine 248 and cysteine 255
Cysteine 52 and cysteine 88 L
A redox-regulated disulphide may form within Receptor-interacting serine/threonine-protein kinase 4 between cysteines 248 and 255.

Details

Redox score ?
78
PDB code
5wnl
Structure name
crystal structure of murine receptor-interacting protein 4 (ripk4) d143n bound to staurosporine
Structure deposition date
2017-08-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
25
Peptide accession
Q9ERK0
Residue number A
248
Residue number B
255
Peptide name
Receptor-interacting serine/threonine-protein kinase 4

Ligandability

Cysteine 248 of Receptor-interacting serine/threonine-protein kinase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Receptor-interacting serine/threonine-protein kinase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-interacting serine/threonine-protein kinase 4 between cysteines 52 and 88. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
5wnl
Structure name
crystal structure of murine receptor-interacting protein 4 (ripk4) d143n bound to staurosporine
Structure deposition date
2017-08-01
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
42
Peptide accession
Q9ERK0
Residue number A
52
Residue number B
88
Peptide name
Receptor-interacting serine/threonine-protein kinase 4

Ligandability

Cysteine 52 of Receptor-interacting serine/threonine-protein kinase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Receptor-interacting serine/threonine-protein kinase 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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