ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Intramolecular
Cysteine 226 and cysteine 227
Cysteine 40 and cysteine 95
A redox-regulated disulphide may form within tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 between cysteines 226 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7u20
Structure name
crystal structure of human mettl1 and wdr4 complex
Structure deposition date
2022-02-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
63
Peptide accession
P57081
Residue number A
226
Residue number B
227
Peptide name
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Ligandability

Cysteine 226 of tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 227 of tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 between cysteines 40 and 95. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7u20
Structure name
crystal structure of human mettl1 and wdr4 complex
Structure deposition date
2022-02-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
58
Peptide accession
P57081
Residue number A
40
Residue number B
95
Peptide name
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Ligandability

Cysteine 40 of tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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