a tool for identifying drug-targetable redox-active disulphides

Krueppel-like factor 3

Intramolecular

Cysteine 321 and cysteine 324

A redox-regulated disulphide may form within Krueppel-like factor 3 between cysteines 321 and 324 (10 and 13 respectively in this structure).

Details

Redox score ?

87

PDB code

Structure name

arg326-trp mutant of the third zinc finger of bklf

Structure deposition date

2004-08-05

Thiol separation (Å)

4

Half-sphere exposure sum ?

38

Minimum pK_a ?

6

% buried

0

Peptide accession

Residue number A

321

Residue number B

324

Peptide name

Krueppel-like factor 3

Ligandability

Cysteine 321 of Krueppel-like factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of Krueppel-like factor 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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