a tool for identifying drug-targetable redox-active disulphides

Caspase recruitment domain-containing protein 18

Intramolecular

Cysteine 69 and cysteine 70

A redox-regulated disulphide may form within Caspase recruitment domain-containing protein 18 between cysteines 69 and 70.

Details

Redox score ?

77

PDB code

Structure name

solution structure of iceberg, an inhibitor of interleukin-1beta generation

Structure deposition date

1999-11-24

Thiol separation (Å)

4

Half-sphere exposure sum ?

54

Minimum pK_a ?

8

% buried

5

Peptide accession

Residue number A

69

Residue number B

70

Peptide name

Caspase recruitment domain-containing protein 18

Ligandability

Cysteine 69 of Caspase recruitment domain-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of Caspase recruitment domain-containing protein 18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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