a tool for identifying drug-targetable redox-active disulphides

Forkhead box protein L2

Intramolecular

Cysteine 111 and cysteine 134

A redox-regulated disulphide may form within Forkhead box protein L2 between cysteines 111 and 134 (60 and 83 respectively in this structure).

Details

Redox score ?

87

PDB code

Structure name

the crystal structure of human forkhead box protein in complex with dna 2

Structure deposition date

2021-10-15

Thiol separation (Å)

2

Half-sphere exposure sum ?

36

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

111

Residue number B

134

Peptide name

Forkhead box protein L2

Ligandability

Cysteine 111 of Forkhead box protein L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Forkhead box protein L2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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