ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Neurexophilin-1

Intramolecular
Cysteine 210 and cysteine 218
Cysteine 194 and cysteine 231
Cysteine 239 and cysteine 256
A redox-regulated disulphide may form within Neurexophilin-1 between cysteines 210 and 218.

Details

Redox score ?
89
PDB code
6pnp
Structure name
crystal structure of the splice insert-free neurexin-1 lns2 domain in complex with neurexophilin-1
Structure deposition date
2019-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
24
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63366
Residue number A
210
Residue number B
218
Peptide name
Neurexophilin-1

Ligandability

Cysteine 210 of Neurexophilin-1

Cysteine 218 of Neurexophilin-1

A redox-regulated disulphide may form within Neurexophilin-1 between cysteines 194 and 231.

Details

Redox score ?
86
PDB code
6pnq
Structure name
crystal structure of the ss2a splice insert-containing neurexin-1 lns2 domain in complex with neurexophilin-1
Structure deposition date
2019-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63366
Residue number A
194
Residue number B
231
Peptide name
Neurexophilin-1

Ligandability

Cysteine 194 of Neurexophilin-1

Cysteine 231 of Neurexophilin-1

A redox-regulated disulphide may form within Neurexophilin-1 between cysteines 239 and 256.

Details

Redox score ?
79
PDB code
6pnq
Structure name
crystal structure of the ss2a splice insert-containing neurexin-1 lns2 domain in complex with neurexophilin-1
Structure deposition date
2019-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63366
Residue number A
239
Residue number B
256
Peptide name
Neurexophilin-1

Ligandability

Cysteine 239 of Neurexophilin-1

Cysteine 256 of Neurexophilin-1

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