a tool for identifying drug-targetable redox-active disulphides

FXYD domain-containing ion transport regulator 4

Intramolecular

Cysteine 61 and cysteine 63

A redox-regulated disulphide may form within FXYD domain-containing ion transport regulator 4 between cysteines 61 and 63 (41 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

53

PDB code

Structure name

solution structure of the human fxyd4 (chif) protein in sds micelles

Structure deposition date

2007-04-18

Thiol separation (Å)

9

Half-sphere exposure sum ?

29

Minimum pK_a ?

9

% buried

0

Peptide accession

Residue number A

61

Residue number B

63

Peptide name

FXYD domain-containing ion transport regulator 4

Ligandability

Cysteine 61 of FXYD domain-containing ion transport regulator 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 of FXYD domain-containing ion transport regulator 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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