a tool for identifying drug-targetable redox-active disulphides

Actin-related protein 2/3 complex subunit 4

Intermolecular

Cysteine 265 of Actin-related protein 2/3 complex subunit 1B and cysteine 21

A redox-regulated disulphide may form between cysteine 265 of Actin-related protein 2/3 complex subunit 1B and cysteine 21 of Actin-related protein 2/3 complex subunit 4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

32

PDB code

Structure name

crystal structure of bovine arp2/3 complex co-crystallized with adp

Structure deposition date

2007-03-26

Thiol separation (Å)

9

Half-sphere exposure sum ?

91

Minimum pK_a ?

11

% buried

100

Peptide A name

Actin-related protein 2/3 complex subunit 1B

Peptide B name

Actin-related protein 2/3 complex subunit 4

Peptide A accession

Peptide B accession

Peptide A residue number

265

Peptide B residue number

21

Ligandability

Cysteine 265 of Actin-related protein 2/3 complex subunit 1B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 21 of Actin-related protein 2/3 complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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