ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Transcription elongation factor 1 homolog

Intramolecular
Cysteine 26 and cysteine 50
Cysteine 50 and cysteine 53
Cysteine 29 and cysteine 50
Cysteine 35 and cysteine 50
Cysteine 26 and cysteine 29
Cysteine 26 and cysteine 53
Cysteine 26 and cysteine 35
Cysteine 29 and cysteine 53
Cysteine 29 and cysteine 35
Cysteine 35 and cysteine 53
More...
Cysteine 26 and cysteine 78
Cysteine 53 and cysteine 78
A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 26 and 50.

Details

Redox score ?
90
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
5
% buried
8
Peptide accession
P60003
Residue number A
26
Residue number B
50
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 26 of Transcription elongation factor 1 homolog

Cysteine 50 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 50 and 53.

Details

Redox score ?
89
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
5
% buried
0
Peptide accession
P60003
Residue number A
50
Residue number B
53
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 50 of Transcription elongation factor 1 homolog

Cysteine 53 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 29 and 50.

Details

Redox score ?
89
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
5
% buried
0
Peptide accession
P60003
Residue number A
29
Residue number B
50
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 29 of Transcription elongation factor 1 homolog

Cysteine 50 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 35 and 50.

Details

Redox score ?
88
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
5
% buried
13
Peptide accession
P60003
Residue number A
35
Residue number B
50
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 35 of Transcription elongation factor 1 homolog

Cysteine 50 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 26 and 29.

Details

Redox score ?
82
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
7
Peptide accession
P60003
Residue number A
26
Residue number B
29
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 26 of Transcription elongation factor 1 homolog

Cysteine 29 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 26 and 53.

Details

Redox score ?
82
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
7
Peptide accession
P60003
Residue number A
26
Residue number B
53
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 26 of Transcription elongation factor 1 homolog

Cysteine 53 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 26 and 35.

Details

Redox score ?
80
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
8
% buried
20
Peptide accession
P60003
Residue number A
26
Residue number B
35
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 26 of Transcription elongation factor 1 homolog

Cysteine 35 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 29 and 53.

Details

Redox score ?
76
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
10
% buried
0
Peptide accession
P60003
Residue number A
29
Residue number B
53
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 29 of Transcription elongation factor 1 homolog

Cysteine 53 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 29 and 35.

Details

Redox score ?
64
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
10
% buried
12
Peptide accession
P60003
Residue number A
29
Residue number B
35
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 29 of Transcription elongation factor 1 homolog

Cysteine 35 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 35 and 53. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
7
Half-sphere exposure sum ?
49
Minimum pKa ?
12
% buried
12
Peptide accession
P60003
Residue number A
35
Residue number B
53
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 35 of Transcription elongation factor 1 homolog

Cysteine 53 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 26 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
7
Peptide accession
P60003
Residue number A
26
Residue number B
78
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 26 of Transcription elongation factor 1 homolog

Cysteine 78 of Transcription elongation factor 1 homolog

A redox-regulated disulphide may form within Transcription elongation factor 1 homolog between cysteines 53 and 78. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
1wii
Structure name
solution structure of rsgi ruh-025, a duf701 domain from mouse cdna
Structure deposition date
2004-05-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
37
Minimum pKa ?
10
% buried
0
Peptide accession
P60003
Residue number A
53
Residue number B
78
Peptide name
Transcription elongation factor 1 homolog

Ligandability

Cysteine 53 of Transcription elongation factor 1 homolog

Cysteine 78 of Transcription elongation factor 1 homolog

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