ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Actin, cytoplasmic 1

Intermolecular
Cysteine 374 and cysteine 374
Intramolecular
Cysteine 217 and cysteine 257 L
A redox-regulated disulphide may form between two units of Actin, cytoplasmic 1 at cysteines 374 and 374.

Details

Redox score ?
88
PDB code
2oan
Structure name
structure of oxidized beta-actin
Structure deposition date
2006-12-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Actin, cytoplasmic 1
Peptide B name
Actin, cytoplasmic 1
Peptide A accession
P60712
Peptide B accession
P60712
Peptide A residue number
374
Peptide B residue number
374

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin, cytoplasmic 1 between cysteines 217 and 257.

Details

Redox score ?
74
PDB code
1hlu
Structure name
structure of bovine beta-actin-profilin complex with actin bound atp phosphates solvent accessible
Structure deposition date
1997-05-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
81
Minimum pKa ?
8
% buried
100
Peptide accession
P60712
Residue number A
217
Residue number B
257
Peptide name
Actin, cytoplasmic 1

Ligandability

Cysteine 217 of Actin, cytoplasmic 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 257 of Actin, cytoplasmic 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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