ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ras-related C3 botulinum toxin substrate 3

Intramolecular
Cysteine 81 and cysteine 157
Cysteine 6 and cysteine 81
A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 3 between cysteines 81 and 157. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2c2h
Structure name
crystal structure of the human rac3 in complex with gdp
Structure deposition date
2005-09-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
P60763
Residue number A
81
Residue number B
157
Peptide name
Ras-related C3 botulinum toxin substrate 3

Ligandability

Cysteine 81 of Ras-related C3 botulinum toxin substrate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of Ras-related C3 botulinum toxin substrate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ras-related C3 botulinum toxin substrate 3 between cysteines 6 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
2ov2
Structure name
the crystal structure of the human rac3 in complex with the crib domain of human p21-activated kinase 4 (pak4)
Structure deposition date
2007-02-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
100
Peptide accession
P60763
Residue number A
6
Residue number B
81
Peptide name
Ras-related C3 botulinum toxin substrate 3

Ligandability

Cysteine 6 of Ras-related C3 botulinum toxin substrate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Ras-related C3 botulinum toxin substrate 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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