ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribose-phosphate pyrophosphokinase 1

Intramolecular
Cysteine 226 and cysteine 230
Cysteine 60 and cysteine 91
Cysteine 230 and cysteine 265
Cysteine 226 and cysteine 284
Cysteine 230 and cysteine 284
A redox-regulated disulphide may form within Ribose-phosphate pyrophosphokinase 1 between cysteines 226 and 230.

Details

Redox score ?
74
PDB code
4m0u
Structure name
crystal structure of human prs1 q133p mutant
Structure deposition date
2013-08-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
60
Peptide accession
P60891
Residue number A
226
Residue number B
230
Peptide name
Ribose-phosphate pyrophosphokinase 1

Ligandability

Cysteine 226 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribose-phosphate pyrophosphokinase 1 between cysteines 60 and 91.

Details

Redox score ?
65
PDB code
3efh
Structure name
crystal structure of human phosphoribosyl pyrophosphate synthetase 1
Structure deposition date
2008-09-08
Thiol separation (Å)
5
Half-sphere exposure sum ?
81
Minimum pKa ?
8
% buried
100
Peptide accession
P60891
Residue number A
60
Residue number B
91
Peptide name
Ribose-phosphate pyrophosphokinase 1

Ligandability

Cysteine 60 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribose-phosphate pyrophosphokinase 1 between cysteines 230 and 265. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
4m0u
Structure name
crystal structure of human prs1 q133p mutant
Structure deposition date
2013-08-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
7
% buried
36
Peptide accession
P60891
Residue number A
230
Residue number B
265
Peptide name
Ribose-phosphate pyrophosphokinase 1

Ligandability

Cysteine 230 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 265 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribose-phosphate pyrophosphokinase 1 between cysteines 226 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
4lzn
Structure name
crystal structure of human prs1 d65n mutant
Structure deposition date
2013-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
58
Peptide accession
P60891
Residue number A
226
Residue number B
284
Peptide name
Ribose-phosphate pyrophosphokinase 1

Ligandability

Cysteine 226 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribose-phosphate pyrophosphokinase 1 between cysteines 230 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2h07
Structure name
crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant s132a
Structure deposition date
2006-05-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
43
Peptide accession
P60891
Residue number A
230
Residue number B
284
Peptide name
Ribose-phosphate pyrophosphokinase 1

Ligandability

Cysteine 230 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Ribose-phosphate pyrophosphokinase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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