ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ras-related protein Rab-8A

Intermolecular
Cysteine 123 and cysteine 123
A redox-regulated disulphide may form between two units of Ras-related protein Rab-8A at cysteines 123 and 123. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6whe
Structure name
structure of phosphomimetic rab8a gtpase (t72e) in the gtp-bound state
Structure deposition date
2020-04-08
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
13
% buried
100
Peptide A name
Ras-related protein Rab-8A
Peptide B name
Ras-related protein Rab-8A
Peptide A accession
P61006
Peptide B accession
P61006
Peptide A residue number
123
Peptide B residue number
123

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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